Gene

hcrt

ID
ZDB-GENE-040324-1
Name
hypocretin (orexin) neuropeptide precursor
Symbol
hcrt Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have neuropeptide hormone activity; type 1 hypocretin receptor binding activity; and type 2 hypocretin receptor binding activity. Involved in several processes, including circadian sleep/wake cycle, wakefulness; multicellular organismal response to stress; and sleep. Predicted to localize to perinuclear region of cytoplasm. Is expressed in brain; female organism; hypocretin-secreting neurons; male organism; and spinal cord. Human ortholog(s) of this gene implicated in narcolepsy. Orthologous to human HCRT (hypocretin neuropeptide precursor).
Genome Resources
Note
None
Expression
All Expression Data
39 figures from 26 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Nishimura et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hcrt Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
narcolepsy Alliance ?Narcolepsy 1 161400
Associated With hcrt Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001704 Prepro-orexin
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations