ZFIN ID: ZDB-GENE-040312-2
Gene Name: cysteine rich transmembrane BMP regulator 1 (chordin-like)
Gene Symbol: crim1    Nomenclature History

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Previous Name: wu:fc29f08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have insulin-like growth factor binding activity and serine-type endopeptidase inhibitor activity. Involved in blood vessel development; notochord morphogenesis; and somitogenesis. Predicted to localize to extracellular region and integral component of membrane. Is expressed in several structures, including axis; intermediate cell mass of mesoderm; notochord; otic vesicle; and posterior segment eye. Used to study cataract and microphthalmia. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1).
Genome Resources: Alliance (1),  Gene:404210 (1),  Ensembl(GRCz11):ENSDARG00000029668 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020131Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027863Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23146 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23147 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23148 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42982 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-crim1 N/A 2
    MO2-crim1 N/A 1
    DISEASE ASSOCIATED WITH crim1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH crim1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    cataract WT + MO1-crim1 standard conditions Brastrom et al., 2019
    microphthalmia WT + MO1-crim1 standard conditions Brastrom et al., 2019
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel development (more)
    Cellular Component extracellular region (more)
    Molecular Function enzyme inhibitor activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA crim1-201 (1)    Ensembl 5458
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM crim1 No data available
    MARKER RELATIONSHIPS
    crim1 Contained in: [BAC] CH211-248E9 (1), DKEY-153J7 (1) (order this), RP71-1A16 (1)
    crim1 Encodes: [EST] fc29f08 (1)
    [cDNA] MGC:193853 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212821 (1) 3144 nt
    Genomic GenBank:BX571670 (1) 213920 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B3DH05 (1) 1027 aa
    Sequence Information (all 20)
    ORTHOLOGY for crim1 ( Chr: 17 )
    CITATIONS (28)