Gene

pik3r2

ID
ZDB-GENE-040309-1
Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Symbol
pik3r2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway; phosphatidylinositol phosphorylation; and regulation of phosphatidylinositol 3-kinase activity. Predicted to localize to phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pik3r2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 603387
Associated With pik3r2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR000980 SH2 domain
Domain IPR001452 SH3 domain
Domain IPR032498 PI3K regulatory subunit p85-related , inter-SH2 domain
Domain IPR035020 PI3K p85 subunit, C-terminal SH2 domain
Domain IPR035022 PI3K p85 subunit, N-terminal SH2 domain
Domain IPR035586 Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain PI3K p85 subunit, C-terminal SH2 domain PI3K p85 subunit, N-terminal SH2 domain PI3K regulatory subunit p85-related , inter-SH2 domain Rho GTPase-activating protein domain Rho GTPase activation protein SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily
UniProtKB:F6NVP6 706
UniProtKB:B3DHG9 724
UniProtKB:A0A2R8QIU7 724
UniProtKB:Q7T208 723
UniProtKB:F1QB84 618
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations