ZFIN ID: ZDB-GENE-040305-2
Gene Name: tnf receptor-associated factor 4b
Gene Symbol: traf4b    Nomenclature History

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Previous Name: traf4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have thioesterase binding activity; tumor necrosis factor receptor binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of JNK cascade. Predicted to localize to the cytoplasm and protein-containing complex. Orthologous to human TRAF4 (TNF receptor associated factor 4).
Genome Resources: Alliance (1),  Gene:404035 (1),  Ensembl(GRCz11):ENSDARG00000038964 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13894 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24012 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH traf4b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH traf4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of NF-kappaB-inducing kinase activity (more)
    Cellular Component cytoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001293 Zinc finger, TRAF-type
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR002083 MATH/TRAF domain
    Domain IPR003613 U box domain
    Homologous_superfamily IPR008974 TRAF-like
    Family IPR012227 TNF receptor-associated factor TRAF
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    Conserved_site IPR017907 Zinc finger, RING-type, conserved site
    Domain IPR018957 Zinc finger, C3HC4 RING-type
    Family IPR027138 TNF receptor-associated factor 4
    Domain IPR037307 TNF receptor-associated factor 4, MATH domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA traf4b-201 (1)    Ensembl 1781
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM traf4b No data available
    MARKER RELATIONSHIPS
    traf4b Contained in: [BAC] CH73-331H18 (1)
    traf4b Encodes: [cDNA] MGC:92390 (1), MGC:192838 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212817 (1) 1773 bp
    Genomic GenBank:CU463284 (1) 104874 bp
    Select Tool
    Polypeptide UniProtKB:Q7T1K1 (1) 478 aa
    Sequence Information (all 14)
    ORTHOLOGY for traf4b ( Chr: 21 )
    CITATIONS (24)