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ZIRC
ZFIN ID: ZDB-GENE-040219-4
Gene Name: toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Gene Symbol: tirap    Nomenclature History

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Previous Names: mal (1), MyD88 adapter-like protein (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in malaria; primary immunodeficiency disease; and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein).
Genome Resources: Alliance (1),  Gene:403148 (1),  Ensembl(GRCz11):ENSDARG00000074371 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa182 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tirap HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Bacteremia, protection against} 614382
    {Malaria, protection against} 611162
    {Pneumococcal disease, invasive, protection against} 610799
    {Tuberculosis, protection against} 607948
    DISEASE ASSOCIATED WITH tirap VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process signal transduction (more)
    GO Terms (all 1)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tirap No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_002667112 (1)
    Genomic GenBank:CABZ01102203 (1) 7894 bp
    Polypeptide UniProtKB:F1Q7L3 (1) 203 aa
    Sequence Clusters UniGene:87438 (1)
    Sequence Information (all 12)
    ORTHOLOGY for tirap ( Chr: 18 )
    CITATIONS (24)