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ZIRC
ZFIN ID: ZDB-GENE-040219-15
Gene Name: toll-like receptor 5b
Gene Symbol: tlr5b    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits Toll-like receptor binding activity and protein heterodimerization activity. Involved in activation of immune response. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5).
Genome Resources: Alliance (1),  Gene:403139 (1),  Ensembl(GRCz11):ENSDARG00000052322 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013935Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6655 Point Mutation Unknown Premature Stop ENU
    sa16424 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tlr5b N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tlr5b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Legionnaire disease, susceptibility to} 608556
    {Melioidosis, susceptibility to} 615557
    {Systemic lupus erythematosus, resistance to} 601744
    {Systemic lupus erythematosus, susceptibility to, 1} 601744
    DISEASE ASSOCIATED WITH tlr5b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process toll-like receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transmembrane signaling receptor activity (more)
    GO Terms (all 15)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tlr5a-201 (1)    Ensembl 2851
    tlr5a-202 (1)    Ensembl 474
    tlr5b-201 (1)    Ensembl 3490
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tlr5b No data available
    MARKER RELATIONSHIPS
    tlr5b Contained in: [Fosmid] CH1073-471M19 (1) (order this)
    tlr5b Encodes: [cDNA] MGC:195156 (1), MGC:195169 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001130595 (1) 2763 bp
    Genomic GenBank:FP017156 (1) 41257 bp
    Select Tool
    Polypeptide UniProtKB:A0A286Y971 (1) 886 aa
    Sequence Clusters UniGene:89707 (1)
    Sequence Information (all 23)
    ORTHOLOGY for tlr5b ( Chr: 20 )
    CITATIONS (50)