Gene

fhl1a

ID
ZDB-GENE-040206-1
Name
four and a half LIM domains 1a
Symbol
fhl1a Nomenclature History
Previous Names
  • fhla
  • zgc:92025
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have ion channel binding activity. Involved in heart development; locomotory behavior; and skeletal muscle satellite cell differentiation. Localizes to Z disc. Is expressed in several structures, including adaxial cell; blastomere; heart rudiment; musculature system; and pericardial region. Used to study myopathy. Human ortholog(s) of this gene implicated in X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1).
Genome Resources
Note
None
Expression
All Expression Data
19 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fhl1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
reducing body myopathy 1A Alliance Reducing body myopathy, X-linked 1a, severe, infantile or early childhood onset 300717
reducing body myopathy 1B Alliance Reducing body myopathy, X-linked 1b, with late childhood or adult onset 300718
scapuloperoneal myopathy Alliance Scapuloperoneal myopathy, X-linked dominant 300695
X-linked Emery-Dreifuss muscular dystrophy 6 Alliance Emery-Dreifuss muscular dystrophy 6, X-linked 300696
X-linked Emery-Dreifuss muscular dystrophy 6 Alliance Myopathy, X-linked, with postural muscle atrophy 300696
?Uruguay faciocardiomusculoskeletal syndrome 300280
Associated With fhl1a Via Experimental Models
Human Disease Fish Conditions Citations
myopathy WT + MO3-fhl1a standard conditions Ke├čler et al., 2018
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001781 Zinc finger, LIM-type
Family IPR037987 Four and a half LIM domains protein 2/3/5
Family IPR042997 Four and a half LIM domains protein 1
Domain Details Per Protein
Protein Length Four and a half LIM domains protein 1 Four and a half LIM domains protein 2/3/5 Zinc finger, LIM-type
UniProtKB:A0A2R8Q5D9 289
UniProtKB:Q6GQL7 297
UniProtKB:Q9W6K4 104
UniProtKB:A0A140LFQ9 281
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations