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Gene

tal2

ID
ZDB-GENE-040115-1
Name
T-cell acute lymphocytic leukemia 2
Symbol
tal2 Nomenclature History
Previous Names
  • zgc:111884
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development and ventral spinal cord interneuron differentiation. Is expressed in floor plate; neurons; and spinal cord. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and adult T-cell leukemia. Orthologous to human TAL2 (TAL bHLH transcription factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Yang et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tal2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance Leukemia, T-cell acute lymphocytic, somatic 613065
Associated With tal2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:Q567M2 109
UniProtKB:F1QUD8 109
UniProtKB:Q6WIH0 109
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations