ZFIN ID: ZDB-GENE-040115-1
Gene Name: T-cell acute lymphocytic leukemia 2
Gene Symbol: tal2    Nomenclature History

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Previous Name: zgc:111884

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in brain development and ventral spinal cord interneuron differentiation. Predicted to localize to nucleus. Is expressed in floor plate; neurons; and spinal cord. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and adult T-cell leukemia. Orthologous to human TAL2 (TAL bHLH transcription factor 2).
Genome Resources: Alliance (1),  Gene:394239 (1),  Ensembl(GRCz11):ENSDARG00000042041 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-tal2 N/A 1
DISEASE ASSOCIATED WITH tal2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance Leukemia, T-cell acute lymphocytic, somatic 613065
DISEASE ASSOCIATED WITH tal2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ventral spinal cord interneuron differentiation (more)
Cellular Component nucleus (more)
Molecular Function protein dimerization activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tal2-201 (1)    Ensembl 655
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tal2 No data available
MARKER RELATIONSHIPS
tal2 Contained in: [BAC] CH73-247J11 (1)
tal2 Encodes: [cDNA] MGC:111884 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_201339 (1) 1283 nt
Genomic GenBank:CU929094 (1) 106785 nt
Select Tool
Polypeptide UniProtKB:F1QUD8 (1) 109 aa
Sequence Information (all 13)
ORTHOLOGY for tal2 ( Chr: 5 )
CITATIONS (27)