ZFIN Gene: nop56

ZFIN ID: ZDB-GENE-040109-1

ZFIN ID: ZDB-GENE-040109-1

Gene Name:

NOP56 ribonucleoprotein homolog

Gene Symbol:

nop56 Nomenclature History

Previous Names:

nol5a, NOP56 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 21 Mapping Details/Browsers

Description:

Predicted to have snoRNA binding activity. Involved in heart development. Predicted to localize to box C/D snoRNP complex and small-subunit processome. Is expressed in midbrain. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein).

Genome Resources:

Alliance (1), Gene:394196 (1), Ensembl(GRCz11):ENSDARG00000012820 (2)

GENE EXPRESSION
All Expression Data:	Fig. 4 from Recher et al., 2013
Wild-type Stages, Structures:	Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
	midbrain posterior margin
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hi3101Tg	Transgenic Insertion	Intron 1	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la010165Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa12582	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE

Data:	3 figures from 3 publications
Observed in:	anatomical system brain central nervous system extension eye fourth ventricle head heart heart contraction hindbrain nervous system pericardium trunk whole organism yolk

DISEASE ASSOCIATED WITH nop56 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spinocerebellar ataxia type 36	Alliance	Spinocerebellar ataxia 36	614153

DISEASE ASSOCIATED WITH nop56 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	heart development (more)
Cellular Component	box C/D snoRNP complex (more)
Molecular Function	snoRNA binding (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
aberrant processed transcript	nop56-201 (1)	836	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	nop56-202 (1)	1134	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	nop56-203 (1)	2039	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	nop56-003 (1)	826	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	nop56-004 (1)	794	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	nop56-005 (1)	799	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	nop56-007 (1)	1014	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM nop56 No data available

MARKER RELATIONSHIPS

nop56 Contained in:

[BAC] CH211-260M19 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_201217 (1)	1610 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CT027620 (1)	162438 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q6DRE5 (1)	548 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 26)

ORTHOLOGY for nop56 ( Chr: 21 )

CITATIONS (30)

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