Gene

nop56

ID

ZDB-GENE-040109-1

Name

NOP56 ribonucleoprotein homolog

Symbol

nop56 Nomenclature History

Previous Names

nol5a
NOP56 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable snoRNA binding activity. Acts upstream of or within several processes, including central nervous system development; swimming behavior; and thigmotaxis. Predicted to be located in nucleolus. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Is expressed in head and midbrain. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nop56 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spinocerebellar ataxia type 36	Alliance	Spinocerebellar ataxia 36	614153

Associated With nop56 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002687	Nop domain
Domain	IPR012974	Nucleolar protein 58/56, N-terminal
Domain	IPR012976	NOSIC
Family	IPR045056	Nucleolar protein Nop56/Nop58
Homologous_superfamily	IPR036070	Nop domain superfamily
Homologous_superfamily	IPR042239	Nop, C-terminal domain

Domain Details Per Protein

Protein	Additional Resources	Length	Nop, C-terminal domain	Nop domain	Nop domain superfamily	NOSIC	Nucleolar protein 58/56, N-terminal	Nucleolar protein Nop56/Nop58
UniProtKB:Q6DRE5	InterPro	548
UniProtKB:A0A8M1P758	InterPro	366

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	nop56-201 (1) Ensembl	Ensembl	836 nt	Select Tool ZFIN BLAST
aberrant processed transcript	nop56-202 (1) Ensembl	Ensembl	1,134 nt	Select Tool ZFIN BLAST
mRNA	nop56-203 (1) Ensembl	Ensembl	2,039 nt	Select Tool ZFIN BLAST
ncRNA	nop56-003 (1) Ensembl	Ensembl	826 nt	Select Tool ZFIN BLAST
ncRNA	nop56-004 (1) Ensembl	Ensembl	794 nt	Select Tool ZFIN BLAST
ncRNA	nop56-005 (1) Ensembl	Ensembl	799 nt	Select Tool ZFIN BLAST
ncRNA	nop56-007 (1) Ensembl	Ensembl	1,014 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations