ZFIN ID: ZDB-GENE-040108-3
Gene Name: cholinergic receptor, nicotinic, alpha 7a (neuronal)
Gene Symbol: chrna7a    Nomenclature History

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Previous Name: chrna7

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Contributes to acetylcholine receptor activity. Involved in response to nicotine. Localizes to acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit).
Genome Resources: Alliance (1),  Gene:394199 (1),  Ensembl(GRCz11):ENSDARG00000101702 (1)
GENE EXPRESSION
All Expression Data: text only from Zirger et al., 2003
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2371 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21086 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21087 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH chrna7a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH chrna7a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to nicotine (more)
    Cellular Component acetylcholine-gated channel complex (more)
    Molecular Function CONTRIBUTES_TO   acetylcholine receptor activity (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chrna7-201 (1)    Ensembl 1612
    ottdart00000002167 (1) 1524
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chrna7a No data available
    MARKER RELATIONSHIPS
    chrna7a Contained in: [BAC] DKEY-215P16 (1) (order this)
    [PAC] BUSM1-70B1
    chrna7a Contains: [STS] chunp40143 (1)
    chrna7a Encodes: [cDNA] MGC:193874 (1), MGC:193893 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201219 (1) 1719 nt
    Genomic GenBank:AL928677 (1) 144076 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IV47 (1) 510 aa
    Sequence Information (all 20)
    ORTHOLOGY for chrna7a ( Chr: 7 )
    CITATIONS (34)