ZFIN ID: ZDB-GENE-031217-3
Gene Name: gap junction protein, alpha 3
Gene Symbol: gja3    Nomenclature History

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Previous Names: Cx44 (1), cx46 (2), cx48.5 (1), dco (1), dococ (1), unm s215, unm s226

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Exhibits gap junction hemi-channel activity. Involved in several processes, including cardiac muscle tissue development; cell communication by electrical coupling; and post-embryonic eye morphogenesis. Predicted to localize to connexin complex and integral component of plasma membrane. Is expressed in several structures, including kidney; liver; pericardial region; retina; and spinal cord. Human ortholog(s) of this gene implicated in cataract 14 multiple types. Orthologous to human GJA3 (gap junction protein alpha 3).
Genome Resources: Alliance (1),  Gene:387533 (1),  Ensembl(GRCz11):ENSDARG00000021889 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 5 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s215 Unknown Unknown Unknown ENU
s226 Point Mutation Unknown Unknown ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-gja3 N/A 2
MO2-gja3 N/A 1
DISEASE ASSOCIATED WITH gja3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 14 multiple types Alliance Cataract 14, multiple types 601885
DISEASE ASSOCIATED WITH gja3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cardiac conduction system development (more)
Cellular Component integral component of plasma membrane (more)
Molecular Function gap junction hemi-channel activity (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gja3-201 (1)    Ensembl 1480
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gja3
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(mitfa:gja3) mitfa gja3 Danio rerio 1 2
Tg(myl7:gja3-EGFP) myl7 EGFPgja3 Danio rerio 1 3
Tg(myl7:gja3_T165I-EGFP) myl7 EGFPgja3 Danio rerio 1 4
MARKER RELATIONSHIPS
gja3 Contained in: [BAC] DKEY-51D17 (1) (order this)
gja3 Encodes: [cDNA] MGC:195070 (1), MGC:195085 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_207642 (1) 1305 nt
Genomic GenBank:CR392366 (1) 125898 nt
Select Tool
Polypeptide UniProtKB:Q8JFD2 (1) 434 aa
Sequence Information (all 33)
ORTHOLOGY for gja3 ( Chr: 9 )
CITATIONS (40)