Gene

ldlra

ID
ZDB-GENE-031217-1
Name
low density lipoprotein receptor a
Symbol
ldlra Nomenclature History
Previous Names
  • ldlr
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Exhibits low-density lipoprotein particle receptor activity. Involved in cellular response to lipopolysaccharide; cholesterol homeostasis; and receptor-mediated endocytosis involved in cholesterol transport. Predicted to localize to integral component of membrane. Is expressed in intestine and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ldlra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial hypercholesterolemia Alliance Hypercholesterolemia, familial, 1 143890
familial hypercholesterolemia Alliance LDL cholesterol level QTL2 143890
Associated With ldlra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
Homologous_superfamily IPR036055 LDL receptor-like superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR000033 LDLR class B repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily LDLR class B repeat LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Six-bladed beta-propeller, TolB-like
UniProtKB:Q7ZZT0 911
UniProtKB:E9QGD4 870
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations