ZFIN ID: ZDB-GENE-031118-95
Gene Name: isocitrate dehydrogenase (NADP(+)) 2
Gene Symbol: idh2    Nomenclature History

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Previous Names: wu:fb33c06, wu:fk31e05, wu:fq43b01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have NAD binding activity; isocitrate dehydrogenase (NADP+) activity; and magnesium ion binding activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Is expressed in several structures, including blastoderm; brain; digestive system; pectoral fin bud; and renal system. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; hepatocellular clear cell carcinoma; and intrahepatic cholangiocarcinoma. Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2).
Genome Resources: Alliance (1),  Gene:386951 (1),  Ensembl(GRCz11):ENSDARG00000003795 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13876 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43120 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-idh2 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH idh2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    D-2-hydroxyglutaric aciduria 2 Alliance D-2-hydroxyglutaric aciduria 2 613657
    DISEASE ASSOCIATED WITH idh2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process isocitrate metabolic process (more)
    Cellular Component mitochondrion (more)
    Molecular Function isocitrate dehydrogenase (NADP+) activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM idh2 No data available
    MARKER RELATIONSHIPS
    idh2 Encodes: [EST] fb33c06 (1), fk31e05, fq43b01
    [cDNA] MGC:55485 (1), MGC:77679 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199564 (1) 1740 nt
    Genomic GenBank:CABZ01039784 (1) 33790 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZUP6 (1) 449 aa
    Sequence Information (all 26)
    ORTHOLOGY for idh2 ( Chr: 18 )
    CITATIONS (31)