ZFIN ID: ZDB-GENE-031118-76
Gene Name: aconitase 1, soluble
Gene Symbol: aco1    Nomenclature History

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Previous Names: IRP1 (1), wu:fo75b03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have aconitate hydratase activity; iron-responsive element binding activity; and iron-sulfur cluster binding activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Predicted to localize to cytosol and mitochondrion. Is expressed in blood and presumptive blood. Orthologous to human ACO1 (aconitase 1).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000026376 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Wingert et al., 2005
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17511 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21154 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27108 Point Mutation Unknown Premature Stop ENU
    sa27109 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-aco1 N/A 2
    MO2-aco1 N/A 1
    MO3-aco1 N/A 1
    DISEASE ASSOCIATED WITH aco1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH aco1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular iron ion homeostasis (more)
    Cellular Component cytoplasm (more)
    Molecular Function 4 iron, 4 sulfur cluster binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aco1 No data available
    MARKER RELATIONSHIPS
    aco1 Encodes: [EST] fo75b03
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:DQ083332 (1) 2673 nt
    Polypeptide UniProtKB:F1QM42 (1) 890 aa
    Sequence Information (all 4)
    ORTHOLOGY for aco1 ( Chr: 7 )
    CITATIONS (21)