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ZIRC
ZFIN ID: ZDB-GENE-031118-36
Gene Name: histone 2, H2, like
Gene Symbol: hist2h2l    Nomenclature History

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Previous Names: H2B (1), fj05g08, wu:fj05g08, zgc:73093 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Predicted to be involved in nucleosome assembly. Localizes to the nuclear chromatin. Is expressed in gill; heart; muscle; pleuroperitoneal region; and proliferative region. Orthologous to several human genes including H2BC21 (H2B clustered histone 21).
Genome Resources: Alliance (1),  Gene:386920 (1),  Ensembl(GRCz11):ENSDARG00000068996 (1)
GENE EXPRESSION
All Expression Data: 17 figures from 3 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2004 [MGC:73093]
  10 figures (26 images) from Rauch et al., 2003 [cegs2546]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34932 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hist2h2l
    2
    CRISPR2-hist2h2l
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hist2h2l HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hist2h2l VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process nucleosome assembly (more)
    Cellular Component nuclear chromatin (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hist2h2l-201 (1)    Ensembl 824
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hist2h2l
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(actb1:hist2h2l-mCherry) actb1 hist2h2lmCherry Danio rerio 1 3
    Tg(actb2:hist2h2l-Citrine-AVI) actb2 Citrinehist2h2l Danio rerio 1 2
    Tg(EPV.Tp1-Mmu.Hbb:hist2h2l-mCherry) hist2h2lmCherry Danio rerioMus musculus 1 31
    Tg(Gga.Egr2:hist2h2l-mCherry) hist2h2lmCherry Danio rerioGallus gallus 1 2
    Tg(hist2h2l:GFP) hist2h2l GFP Danio rerio 1 3
    Tg(kdrl:hist2h2l-EGFP) kdrl EGFPhist2h2l Danio rerio 1 7
    Tg(Xla.Eef1a1:hist2h2l-mCherry) hist2h2lmCherry Danio rerioXenopus laevis 1 2
    Tg(Xla.Eef1a1:hist2h2l-Venus) hist2h2lVenus Danio rerioXenopus laevis 1 5
    MARKER RELATIONSHIPS
    hist2h2l Contained in: [BAC] RP71-56I13 (1) (order this)
    hist2h2l Encodes: [EST] cegs2546 (1) (order this), fj05g08
    [cDNA] MGC:73093 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200117 (1) 840 bp
    Genomic GenBank:BX120005 (1) 129782 bp
    Select Tool
    Polypeptide UniProtKB:Q6PC60 (1) 126 aa
    Sequence Clusters UniGene:24294 (1)
    Sequence Information (all 13)
    ORTHOLOGY for hist2h2l ( Chr: 10 )
    CITATIONS (67)