ZFIN ID: ZDB-GENE-031118-30
Gene Name: RAB5C, member RAS oncogene family
Gene Symbol: rab5c    Nomenclature History

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Previous Names: wu:fb98b08, wu:fi16g01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have GTPase activity. Involved in several processes, including angiogenesis; gastrulation with mouth forming second; and regulation of endocytosis. Localizes to early endosome. Is expressed in axial vasculature; blood; and intermediate cell mass of mesoderm. Orthologous to human RAB5C (RAB5C, member RAS oncogene family).
Genome Resources: Alliance (1),  Gene:386807 (1),  Ensembl(GRCz11):ENSDARG00000026712 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [IMAGE:7143044]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023931Tg Transgenic Insertion Unknown Unknown DNA
sa44559 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rab5c N/A 3
    MO2-rab5c N/A 1
    MO3-rab5c N/A 2
    DISEASE ASSOCIATED WITH rab5c HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rab5c VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component early endosome (more)
    Molecular Function protein binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rab5c-201 (1)    Ensembl 2264
    rab5c-202 (1)    Ensembl 747
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM rab5c
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(actb2:egfp-rab5c) actb2 EGFPrab5c Danio rerio 1 1
    tg(actb2:mcherry-rab5c) actb2 mCherryrab5c Danio rerio 1 2
    Tg(h2ax:EGFP-rab5c) h2ax EGFPrab5c Danio rerio 1 9
    Tg(krt18a.1:rab5c-Venus) krt18a.1 rab5cVenus Danio rerio 1 1
    Tg(UAS:mCherry-rab5c_Q81L) UAS mCherryrab5c Danio rerio 1 4
    Tg(UAS:mCherry-rab5c_S36N) UAS mCherryrab5c Danio rerio 1 6
    MARKER RELATIONSHIPS
    rab5c Contained in: [BAC] CH211-210G13 (1)
    rab5c Encodes: [EST] fb98b08, fi16g01, IMAGE:7143044 (1)
    [cDNA] MGC:55826 (1), MGC:77261 (1), MGC:192222 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201501 (1) 2268 nt
    Genomic GenBank:BX005093 (1) 155392 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZVP2 (1) 221 aa
    Sequence Information (all 23)
    ORTHOLOGY for rab5c ( Chr: 3 )
    CITATIONS (51)