Gene

rbpja

ID
ZDB-GENE-031117-1
Name
recombination signal binding protein for immunoglobulin kappa J region a
Symbol
rbpja Nomenclature History
Previous Names
  • rbpj (1)
  • ik:tdsubc_1e8
  • rbpsuh (1)
  • Su(H)1 (1)
  • Su(H) (1)
  • tdsubc_1e8
  • xx:tdsubc_1e8
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have RNA polymerase II repressing transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including animal organ development; blood vessel development; and embryonic pattern specification. Predicted to localize to MAML1-RBP-Jkappa- ICN1 complex; nucleus; and transcription regulator complex. Is expressed in head; midbrain; and otic vesicle. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rbpja Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Adams-Oliver syndrome Alliance Adams-Oliver syndrome 3 614814
Associated With rbpja Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR015350 Beta-trefoil DNA-binding domain
Domain IPR015351 RBP-J/Cbf11/Cbf12, DNA binding
Domain IPR038007 RBP-Jkappa, IPT domain
Family IPR040159 Suppressor of hairless-like
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR036358 Beta-trefoil domain superfamily
Homologous_superfamily IPR037095 RBP-J/Cbf11/Cbf12, DNA binding domain superfamily
Domain Details Per Protein
Protein Length Beta-trefoil DNA-binding domain Beta-trefoil domain superfamily Immunoglobulin E-set Immunoglobulin-like fold p53-like transcription factor, DNA-binding RBP-J/Cbf11/Cbf12, DNA binding RBP-J/Cbf11/Cbf12, DNA binding domain superfamily RBP-Jkappa, IPT domain Suppressor of hairless-like
UniProtKB:Q561X6 311
UniProtKB:Q6YLA3 498
UniProtKB:A4FTT3 496
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations