ZFIN ID: ZDB-GENE-031105-1
Gene Name: dihydropyrimidinase like 2b
Gene Symbol: dpysl2b    Nomenclature History

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Previous Names: CRMP-2 (1), CRMP2 (1), dpysl2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and microtubule binding activity. Involved in axon regeneration and axonogenesis. Localizes to the cytosol. Is expressed in nervous system; neural plate; otic vesicle; spinal cord neural tube; and trigeminal placode. Orthologous to human DPYSL2 (dihydropyrimidinase like 2).
Genome Resources: Alliance (1),  Gene:553412 (1),  Ensembl(GRCz11):ENSDARG00000032083 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011810Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la017425Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41632 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dpysl2b N/A 2
    MO2-dpysl2b N/A 1
    MO3-dpysl2b N/A 3
    DISEASE ASSOCIATED WITH dpysl2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dpysl2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component cytosol (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR006680 Amidohydrolase-related
    Homologous_superfamily IPR011059 Metal-dependent hydrolase, composite domain superfamily
    Family IPR011778 Hydantoinase/dihydropyrimidinase
    Family IPR030615 Dihydropyrimidinase-related protein 2
    Homologous_superfamily IPR032466 Metal-dependent hydrolase
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dpysl2b-201 (1)    Ensembl 2087
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dpysl2b No data available
    MARKER RELATIONSHIPS
    dpysl2b Contained in: [BAC] CH211-136O4 (1), CH211-217K11 (1)
    dpysl2b Encodes: [cDNA] MGC:158133 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020517 (1) 2590 bp
    Genomic GenBank:AL928672 (1) 187939 bp
    Select Tool
    Polypeptide UniProtKB:Q52PJ3 (1) 573 aa
    Sequence Information (all 18)
    ORTHOLOGY for dpysl2b ( Chr: 10 )
    CITATIONS (30)