ZFIN ID: ZDB-GENE-031030-8
Gene Name: cytochrome P450, family 2, subfamily AA, polypeptide 3
Gene Symbol: cyp2aa3    Nomenclature History

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Previous Name: zgc:63546

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in several processes, including exogenous drug catabolic process; organic acid metabolic process; and xenobiotic metabolic process. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in acute myeloid leukemia; asthma; autoimmune hepatitis; precursor lymphoblastic lymphoma/leukemia; and rhinitis. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6).
Genome Resources: Alliance (1),  Gene:386638 (1),  Ensembl(GRCz11):ENSDARG00000103347 (1)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31096 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44050 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cyp2aa3,cyp2aa9 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp2aa3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp2aa3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heme binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001128 Cytochrome P450
    Family IPR002401 Cytochrome P450, E-class, group I
    Conserved_site IPR017972 Cytochrome P450, conserved site
    Homologous_superfamily IPR036396 Cytochrome P450 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp2aa3-201 (1)    Ensembl 1704
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp2aa3 No data available
    MARKER RELATIONSHIPS
    cyp2aa3 Contained in: [BAC] CH211-121B5 (1), DKEY-12M15 (1) (order this)
    cyp2aa3 Encodes: [cDNA] MGC:63546 (1), MGC:194762 (1), MGC:194781 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198369 (1) 1718 bp
    Genomic GenBank:CT997819 (1) 189527 bp
    Select Tool
    Polypeptide UniProtKB:A0PGL9 (1) 496 aa
    Sequence Information (all 20)
    ORTHOLOGY for cyp2aa3 ( Chr: 23 )
    CITATIONS (23)