ZFIN ID: ZDB-GENE-031030-15
Gene Name: DNA-damage inducible protein 2
Gene Symbol: ddi2    Nomenclature History

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Previous Name: zgc:63515 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have identical protein binding activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; proteasomal protein catabolic process; and regulation of DNA stability. Predicted to localize to chromosome and cytosol. Orthologous to several human genes including DDI2 (DNA damage inducible 1 homolog 2).
Genome Resources: Alliance (1),  Gene:386644 (1),  Ensembl(GRCz11):ENSDARG00000006477 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63515]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la025563Tg Transgenic Insertion Unknown Unknown DNA
sa20777 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ddi2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ddi2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to hydroxyurea (more)
    Cellular Component chromosome (more)
    Molecular Function aspartic-type endopeptidase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ddi2-201 (1)    Ensembl 4083
    ddi2-202 (1)    Ensembl 1444
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ddi2 No data available
    MARKER RELATIONSHIPS
    ddi2 Contained in: [BAC] CH73-15B2 (1)
    ddi2 Encodes: [EST] fc36h07 (1)
    [cDNA] MGC:63515 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_198375 (1) 3985 nt
    Genomic GenBank:CU463231 (1) 104010 nt
    Select Tool
    Polypeptide UniProtKB:Q6TH22 (1) 411 aa
    Sequence Information (all 18)
    ORTHOLOGY for ddi2 ( Chr: 6 )
    CITATIONS (28)