ZFIN ID: ZDB-GENE-031027-1
Gene Name: anaplastic lymphoma receptor tyrosine kinase
Gene Symbol: alk
Previous Name: chunp9946
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, fin, forebrain, heart (all 8) expand
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la020189Tg
Knockdown reagents: MO1-alk (1), MO2-alk (1), MO3-alk (1)
PHENOTYPE
Data: 3 figures from Yao et al., 2013
Observed in: brain neuron, hindbrain, neuron, neuron differentiation

Phenotype of Human Orthologue OMIM Phenotype ID
{Neuroblastoma, susceptibility to, 3} 613014
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of neuron differentiation (more)
Cellular Component integral component of membrane (more)
Molecular Function transmembrane receptor protein tyrosine kinase activity (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR000998 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002011 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR026830 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00239 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50060 (1)
  • Pfam:PF00629 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA alk-001 (1) 8881
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alk
    Tg(HSE:alk,CFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    alk Contained in: [BAC] DKEYP-47F9
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_686872 (1) 5229 bp
    Genomic GenBank:BX663528 (1) 193986 bp
    Select Tool
    Polypeptide UniProtKB:F8W3R9 (1) 1181 aa
    Sequence Clusters UniGene:108662 (1)
    Sequence Information (all 6)
    OTHER alk GENE PAGES
  • Gene:563509 (1)
  • VEGA:OTTDARG00000033980 (1)
  • Ensembl(Zv9):ENSDARG00000095833 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # NT
    Zebrafish alk 17  
    Human ALK 2 (2p23)
  • OMIM:105590
  • Gene:238
  • Orthology Details
    CITATIONS (18)