ZFIN ID: ZDB-GENE-031027-1
Gene Name: anaplastic lymphoma receptor tyrosine kinase
Gene Symbol: alk
Previous Name: chunp9946
Location: Chr: 17 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, fin, forebrain, heart (all 8) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
la020189Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-alk (1), MO2-alk (1), MO3-alk (1)
    PHENOTYPE
    Data: 3 figures from Yao et al., 2013
    Observed in: brain neuron, hindbrain, neuron, neuron differentiation
    DISEASE ASSOCIATED WITH alk HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    neuroblastoma {Neuroblastoma, susceptibility to, 3} 613014
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of neuron differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transmembrane receptor protein tyrosine kinase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR000998 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002011 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00239 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50060 (1)
  • Pfam:PF00629 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA alk-001 (1) 8881
    GENE PRODUCT DESCRIPTION
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM alk
    Tg(HSE:alk,CFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    alkContained in: [BAC] DKEYP-47F9
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_686872 (1) 5229bp
    Genomic GenBank:BX663528 (1) 193986bp
    Select Tool
    Polypeptide UniProtKB:F8W3R9 (1) 1181aa
    Sequence Clusters UniGene:108662 (1)
    Sequence Information (all 7)
    OTHER alk GENE PAGES
  • Gene:563509 (1)
  • VEGA:OTTDARG00000033980 (1)
  • Ensembl(GRCz10):ENSDARG00000095833 (1)
  • ORTHOLOGY for alk (Chr: 17)
    Species Symbol Chromosome Accession # Evidence
    Human ALK 2
  • Gene:238
  • OMIM:105590
  • HGNC:427
  • Nucleotide sequence comparison (1)
    Download Curated Orthology
    CITATIONS (18)