ZFIN ID: ZDB-GENE-031007-5
Gene Name: v-akt murine thymoma viral oncogene homolog 2
Gene Symbol: akt2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in several processes, including bone development; glucose homeostasis; and positive regulation of glucose import. Is expressed in several structures, including brain; gill; heart; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); malignant glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2).
Genome Resources: Alliance (1),  Gene:378972 (1),  Ensembl(GRCz11):ENSDARG00000011219 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb504 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb505 Insertion Unknown Unknown CRISPR
    la020441Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7448 Point Mutation Unknown Missense ENU
    sa23364 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-akt2 1
    MO1-akt2 N/A 1
    MO2-akt2 N/A 1
    DISEASE ASSOCIATED WITH akt2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    type 2 diabetes mellitus Alliance Diabetes mellitus, type II 125853
    Hypoinsulinemic hypoglycemia with hemihypertrophy 240900
    DISEASE ASSOCIATED WITH akt2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process bone development (more)
    Molecular Function ATP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA akt2-201 (1)    Ensembl 3363
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM akt2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(lyz:akt2-EGFP) lyz akt2EGFP Danio rerio 1 4
    MARKER RELATIONSHIPS
    akt2 Contained in: [BAC] CH73-76G6 (1), CH211-132B12 (1)
    akt2 Encodes: [cDNA] MGC:153876 (1), MGC:192688 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_198146 (1) 3364 nt
    Genomic GenBank:BX664607 (1) 179328 nt
    Select Tool
    Polypeptide UniProtKB:Q8UUX0 (1) 479 aa
    Sequence Information (all 15)
    ORTHOLOGY for akt2 ( Chr: 18 )
    CITATIONS (44)