ZFIN ID: ZDB-GENE-031007-2
Gene Name: sirtuin 6
Gene Symbol: sirt6    Nomenclature History

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Previous Name: zgc:86729

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have NAD+ binding activity. Is expressed in liver and retina. Orthologous to human SIRT6 (sirtuin 6).
Genome Resources: Alliance (1),  Gene:415161 (1),  Ensembl(GRCz11):ENSDARG00000102963 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6897658]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-sirt6 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH sirt6 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH sirt6 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Molecular Function NAD+ binding (more)
GO Terms (all 1)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR003000 Sirtuin family
Domain IPR026590 Sirtuin family, catalytic core domain
Homologous_superfamily IPR029035 DHS-like NAD/FAD-binding domain superfamily
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM sirt6 No data available
MARKER RELATIONSHIPS
sirt6 Contained in: [BAC] CH211-182E10 (1)
sirt6 Encodes: [EST] IMAGE:6897658 (1)
[cDNA] MGC:86729 (1), MGC:174396 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001002071 (1) 1448 bp
Genomic GenBank:CR384061 (1) 147179 bp
Select Tool
Polypeptide UniProtKB:A8E5H0 (1) 354 aa
Sequence Information (all 31)
ORTHOLOGY for sirt6 ( Chr: 2 )
CITATIONS (22)