Gene
pld1a
- ID
- ZDB-GENE-031002-2
- Name
- phospholipase D1a
- Symbol
- pld1a Nomenclature History
- Previous Names
-
- pld1
- si:ch211-244m8.2
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Exhibits phospholipase D activity. Involved in angiogenesis. Predicted to localize to Golgi apparatus. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Is expressed in liver; notochord; pharyngeal pouch; and somite. Orthologous to human PLD1 (phospholipase D1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Zeng et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental cardiac valvular defect | Alliance | Cardiac valvular dysplasia 1 | 212093 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001683 | Phox homology |
| Domain | IPR001736 | Phospholipase D/Transphosphatidylase |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR025202 | Phospholipase D-like domain |
| Family | IPR015679 | Phospholipase D family |
| Family | IPR016555 | Phospholipase D, eukaryotic type |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR036871 | PX domain superfamily |
Domain Details Per Protein
| Protein | Length | PH-like domain superfamily | Phospholipase D, eukaryotic type | Phospholipase D family | Phospholipase D-like domain | Phospholipase D/Transphosphatidylase | Phox homology | Pleckstrin homology domain | PX domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B0V1J1
|
1022 |
Interactions and Pathways
No data available
Plasmids
No data available