ZFIN Gene: atp2b1a

ZFIN ID: ZDB-GENE-030925-29

ZFIN ID: ZDB-GENE-030925-29

Gene Name:

ATPase plasma membrane Ca2+ transporting 1a

Gene Symbol:

atp2b1a Nomenclature History

Previous Names:

pmca1a (1), sb:cb801, si:dkey-18o7.1, wu:fe47b06, wu:fi41d01

Gene Type:

protein_coding_gene

Location:

Chr: 4 Mapping Details/Browsers

Description:

Predicted to have PDZ domain binding activity and calcium transmembrane transporter activity, phosphorylative mechanism. Involved in animal organ development and sensory perception of sound. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in several structures, including digestive system; hematopoietic system; midbrain neural tube; nervous system; and pleuroperitoneal region. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1).

Genome Resources:

Alliance (1), Gene:378746 (1), Ensembl(GRCz11):ENSDARG00000012684 (2)

GENE EXPRESSION
All Expression Data:	24 figures from 7 publications
Directly Submitted Expression Data:	6 figures (12 images) from Thisse et al., 2001 [cb801]
	6 figures (10 images) from Thisse et al., 2004 [IMAGE:7139107]
	4 figures (16 images) from Rauch et al., 2003 [fq35e10]
	1 figure (1 image) from Thisse et al., 2004 [IMAGE:7165930]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	alar plate midbrain region basal plate midbrain region blood brain central nervous system cranial ganglion diencephalon eye gill hair cell anterior macula hair cell posterior macula hindbrain infraorbital lateral line neuromast inner ear integument intermediate cell mass of mesoderm intestine kidney lagena lateral line system lens liver macula macula lagena hair cell macula lagena mandibular lateral line neuromast midbrain middle lateral line neuromast muscle pioneer neuromast neuron occipital lateral line neuromast olfactory placode opercular lateral line neuromast optic stalk optic tectum otic lateral line neuromast otic placode otic vesicle ovary peripheral olfactory organ pharyngeal epithelium posterior lateral line neuromast posterior lateral line primordium protoneuromast primary neuron retina saccule solid lens vesicle somite spinal cord spleen tegmentum telencephalon tooth 4V tooth placode trigeminal placode ventral mesoderm whole organism yolk syncytial layer
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa33434	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40264	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-atp2b1a	N/A	1
MO2-atp2b1a	N/A	2

PHENOTYPE

Data:

9 figures from 3 publications

Observed in:

DISEASE ASSOCIATED WITH atp2b1a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH atp2b1a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	bone mineralization (more)
Cellular Component	integral component of membrane (more)
Molecular Function	ATP binding (more)

GO Terms (all 20)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	atp2b1a-201 (1)	5951	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM atp2b1a No data available

MARKER RELATIONSHIPS

atp2b1a Contained in:	[BAC] DKEY-18O7 (1) (order this)
atp2b1a Encodes:	[EST] cb801 (1) (order this), fe47b06 (1), fi41d01 (1), fq35e10 (1) (order this), IMAGE:7139107 (1), IMAGE:7165930 (1) [cDNA] MGC:198349 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001044757 (1)	5951 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX649423 (1)	182374 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F6PDY7 (1)	1228 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 46)

ORTHOLOGY for atp2b1a ( Chr: 4 )

CITATIONS (36)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: