ZFIN ID: ZDB-GENE-030922-1
Gene Name: seven in absentia homolog 2 (Drosophila)-like
Gene Symbol: siah2l    Nomenclature History

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Previous Names: siaz (1), zgc:66284

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of circadian rhythm. Predicted to localize to the nucleus. Is expressed in dorsal aorta; gut; male organism; nervous system; and otic vesicle. Orthologous to several human genes including SIAH2 (siah E3 ubiquitin protein ligase 2).
Genome Resources: Alliance (1),  Gene:378728 (1),  Ensembl(GRCz11):ENSDARG00000044381 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24011 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-siah2l N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH siah2l HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH siah2l VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitotic cell cycle checkpoint (more)
    Cellular Component nucleus (more)
    Molecular Function ubiquitin protein ligase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR013010 Zinc finger, SIAH-type
    Domain IPR018121 Seven-in-absentia protein, TRAF-like domain
    Family IPR004162 E3 ubiquitin-protein ligase SINA-like
    Homologous_superfamily IPR008974 TRAF-like
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA siah2l-201 (1)    Ensembl 1787
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM siah2l No data available
    MARKER RELATIONSHIPS
    siah2l Contained in: [BAC] CH73-40H21 (1), CH211-241L3 (1)
    siah2l Encodes: [cDNA] MGC:66284 (1), MGC:192189 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200427 (1) 1206 nt
    Genomic GenBank:AL935199 (1) 139520 nt
    Select Tool
    Polypeptide UniProtKB:Q7SYL3 (1) 331 aa
    Sequence Information (all 23)
    ORTHOLOGY for siah2l ( Chr: 21 )
    CITATIONS (25)