ZFIN ID: ZDB-GENE-030918-1
Gene Name: epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Gene Symbol: egfra
Sequence Ontology ID : SO:0000704

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Previous Names: egfr, erbb1a (1)

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(Including Attributions)
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 7 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  brain, fin, gill, intestine (all 12) expand
PHENOTYPE
Data: Fig. S9 from Zhao et al., 2013
Observed in: dorsal aorta blood vessel lumenization, dorsal aorta
DISEASE ASSOCIATED WITH egfra HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
lung cancer Adenocarcinoma of lung, response to tyrosine kinase inhibitor in 211980
Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in 211980
{Nonsmall cell lung cancer, susceptibility to} 211980
?Inflammatory skin and bowel disease, neonatal, 2 616069
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel lumenization (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000494 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR006211 (1)
  • InterPro:IPR006212 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR016245 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR032675 (1)
  • InterPro:IPR032778 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00757 (1)
  • Pfam:PF01030 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF14843 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA egfra-001 (1) 3168
    egfra-002 (1) 3007
    egfra-003 (1) 2437
    egfra-004 (1) 1868
    ncRNA egfra-005 (1) 1889
    egfra-006 (1) 518
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM egfra No data available
    MARKER RELATIONSHIPS
    egfraContained in: [BAC] CH73-221H17 (1) (order this), DKEY-283M16 (1) (order this)
    [Fosmid] ZFOS-728C2 (1)
    egfraEncodes: [cDNA] MGC:194806 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_194424 (1) 6169bp
    Genomic GenBank:CR788232 (1) 70979bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IFV9 (1) 1191aa
    Sequence Clusters UniGene:82227 (1)
    Sequence Information (all 38)
    OTHER egfra GENE PAGES
  • Alliance (1)
  • Gene:378478 (1)
  • VEGA:OTTDARG00000019585 (1)
  • Ensembl(GRCz10):ENSDARG00000013847 (1)
  • ORTHOLOGY for egfra (Chr: 2)
    CITATIONS (47)