ZFIN ID: ZDB-GENE-030918-1
Gene Name: epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Gene Symbol: egfra    Nomenclature History

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Previous Names: egfr, erbb1a (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in blood vessel lumenization. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Is expressed in several structures, including gill; lens; liver; pleuroperitoneal region; and somite. Human ortholog(s) of this gene implicated in several diseases, including breast carcinoma; colorectal cancer; lung cancer (multiple); pancreatic cancer; and prostate cancer. Orthologous to human EGFR (epidermal growth factor receptor).
Genome Resources: Alliance (1),  Gene:378478 (1),  Ensembl(GRCz11):ENSDARG00000013847 (2)
DISEASE ASSOCIATED WITH egfra HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lung cancer Alliance Adenocarcinoma of lung, response to tyrosine kinase inhibitor in 211980
Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in 211980
{Nonsmall cell lung cancer, susceptibility to} 211980
?Inflammatory skin and bowel disease, neonatal, 2 616069
DISEASE ASSOCIATED WITH egfra VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel lumenization (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 24)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA egfra-201 (1)    Ensembl 1868
egfra-203 (1)    Ensembl 2437
egfra-205 (1)    Ensembl 3168
egfra-206 (1)    Ensembl 3007
ncRNA egfra-006 (1)    Ensembl 518
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM egfra No data available
MARKER RELATIONSHIPS
egfra Contained in: [BAC] CH73-221H17 (1), DKEY-283M16 (1) (order this)
[Fosmid] ZFOS-728C2 (1)
egfra Encodes: [cDNA] MGC:194806 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_194424 (1) 6169 nt
Genomic GenBank:CR788232 (1) 70979 nt
Select Tool
Polypeptide UniProtKB:A0A0R4IFV9 (1) 1191 aa
Sequence Information (all 37)
ORTHOLOGY for egfra ( Chr: 2 )
CITATIONS (62)