ZFIN ID: ZDB-GENE-030916-2
Gene Name: contactin associated protein 1
Gene Symbol: cntnap1    Nomenclature History

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Previous Names: caspr1, si:ch211-250i3.4, zmp:0000000749

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Predicted to be involved in paranodal junction assembly. Predicted to localize to integral component of membrane and paranode region of axon. Is expressed in posterior lateral line nerve. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome and neuromuscular disease. Orthologous to human CNTNAP1 (contactin associated protein 1).
Genome Resources: Alliance (1),  Gene:566220 (1),  Ensembl(GRCz11):ENSDARG00000074524 (1)
GENE EXPRESSION
All Expression Data: Fig. S4 from Voas et al., 2007
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12772 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26120 Point Mutation Unknown Premature Stop ENU
    sa31346 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cntnap1
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cntnap1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hypomyelinating neuropathy, congenital, 3 618186
    Lethal congenital contracture syndrome 7 616286
    DISEASE ASSOCIATED WITH cntnap1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process paranodal junction assembly (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cntnap1-202 (1)    Ensembl 4033
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cntnap1 No data available
    MARKER RELATIONSHIPS
    cntnap1 Contained in: [BAC] CH211-250I3
    cntnap1 Contains: [STS] z35724-a3749h07.q1c (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_689488 (1) 4652 nt
    Genomic GenBank:AL929523 (1) 133678 nt
    Select Tool
    Polypeptide UniProtKB:X1WGG7 (1) 1309 aa
    Sequence Information (all 7)
    ORTHOLOGY for cntnap1 ( Chr: 3 )
    CITATIONS (18)