ZFIN ID: ZDB-GENE-030912-14
Gene Name: heterogeneous nuclear ribonucleoprotein A1b
Gene Symbol: hnrnpa1b    Nomenclature History

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Previous Names: hnrnpa1, hnrpa1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have mRNA binding activity. Predicted to be involved in germ cell development. Predicted to localize to the nucleus and ribonucleoprotein complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with Paget disease of bone and frontotemporal dementia; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1).
Genome Resources: Alliance (1),  Gene:378453 (1),  Ensembl(GRCz11):ENSDARG00000036675 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6909113]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39423 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hnrnpa1b
    2
    CRISPR2-hnrnpa1b
    2
    MO1-hnrnpa1b N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hnrnpa1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    amyotrophic lateral sclerosis type 20 Alliance Amyotrophic lateral sclerosis 20 615426
    inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 Alliance ?Inclusion body myopathy with early-onset Paget disease without frontotemporal dementia 3 615424
    DISEASE ASSOCIATED WITH hnrnpa1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of RNA metabolic process (more)
    Cellular Component viral nucleocapsid (more)
    Molecular Function mRNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000504 RNA recognition motif domain
    Domain IPR034803 hnRNP A1, RNA recognition motif 2
    Family IPR021662 Nuclear factor hnRNPA1
    Family IPR037366 BOULE/DAZ family
    Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    Homologous_superfamily IPR035979 RNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript hnrnpa1b-202 (1)    Ensembl 1005
    mRNA hnrnpa1b-201 (1)    Ensembl 1564
    hnrnpa1b-203 (1)    Ensembl 620
    hnrnpa1b-204 (1)    Ensembl 473
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hnrnpa1b No data available
    MARKER RELATIONSHIPS
    hnrnpa1b Contained in: [BAC] DKEY-174K1 (1) (order this)
    hnrnpa1b Encodes: [EST] IMAGE:6909113 (1)
    [cDNA] MGC:55638 (1)
    hnrnpa1b Has Artifact: [cDNA] MGC:56623
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200104 (1) 1646 nt
    Genomic GenBank:BX571773 (1) 135439 nt
    Select Tool
    Polypeptide UniProtKB:Q803K3 (1) 422 aa
    Sequence Information (all 14)
    ORTHOLOGY for hnrnpa1b ( Chr: 23 )
    CITATIONS (30)