Gene

hcfc1a

ID

ZDB-GENE-030912-10

Name

host cell factor C1a

Symbol

hcfc1a Nomenclature History

Previous Names

hcfc1
etID52682.11 (1)
fc61g09
im:7159458
wu:fc61g09 (1)
wu:fj40c12

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in chromatin remodeling; histone H4 acetylation; and regulation of transcription, DNA-templated. Predicted to localize to Ada2/Gcn5/Ada3 transcription activator complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human HCFC1 (host cell factor C1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7159458 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from Castro et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hcfc1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
methylmalonic acidemia and homocysteinemia cblX type	Alliance	Methylmalonic aciduria and homocysteinemia, cblX type	309541

Associated With hcfc1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003961	Fibronectin type III
Family	IPR043536	Host cell factor
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR015915	Kelch-type beta propeller
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Repeat	IPR006652	Kelch repeat type 1