ZFIN ID: ZDB-GENE-030912-10
Gene Name: host cell factor C1a
Gene Symbol: hcfc1a    Nomenclature History

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Previous Names: hcfc1, etID52682.11 (1), fc61g09, im:7159458, wu:fc61g09 (1), wu:fj40c12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to localize to the MLL1 complex and Set1C/COMPASS complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human HCFC1 (host cell factor C1).
Genome Resources: Alliance (1),  Gene:564853 (1),  Ensembl(GRCz11):ENSDARG00000015990 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7159458]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la017800Tg Transgenic Insertion Unknown Unknown DNA
la027259Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21913 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hcfc1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hcfc1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mental retardation, X-linked 3 (methylmalonic acidemia and homocysteinemia, cblX type ) 309541
    DISEASE ASSOCIATED WITH hcfc1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chromatin remodeling (more)
    Cellular Component MLL1 complex (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003961 Fibronectin type III
    Repeat IPR006652 Kelch repeat type 1
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR015915 Kelch-type beta propeller
    Homologous_superfamily IPR036116 Fibronectin type III superfamily
    Family IPR037854 Host cell factor 1
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hcfc1a-201 (1)    Ensembl 6964
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hcfc1a No data available
    MARKER RELATIONSHIPS
    hcfc1a Contained in: [BAC] DKEY-13A21 (order this), DKEY-245F22 (1) (order this), DKEYP-97E7 (1)
    hcfc1a Encodes: [EST] fc61g09, fj40c12, IMAGE:7159458 (1)
    [cDNA] MGC:158156 (1), MGC:158300 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045064 (1) 6952 bp
    Genomic GenBank:AL844847 235174 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q750 (1) 1802 aa
    Sequence Information (all 31)
    ORTHOLOGY for hcfc1a ( Chr: 11 )
    CITATIONS (30)