ZFIN is now using GRCz12tu for Genomic Data
Gene
grem2b
- ID
- ZDB-GENE-030911-9
- Name
- gremlin 2, DAN family BMP antagonist b
- Symbol
- grem2b Nomenclature History
- Previous Names
-
- grem2
- prdc (1)
- zgc:112207
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable BMP binding activity and receptor ligand activity. Acts upstream of or within BMP signaling pathway; cartilage morphogenesis; and heart development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; head; optic cup; optic vesicle; and swim bladder bud. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Tooth agenesis, selective, 9 | 617275 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine knot, C-terminal | Cystine-knot cytokine | DAN | Gremlin-1/2 |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AYP8 | InterPro | 222 | ||||
| UniProtKB:Q566Z5 | InterPro | 166 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grem2b-201
(1)
|
Ensembl | 866 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers