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General Information
ZIRC
ZFIN ID: ZDB-GENE-030911-9
Gene Name: gremlin 2, DAN family BMP antagonist b
Gene Symbol: grem2b    Nomenclature History

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Previous Names: grem2, prdc (1), zgc:112207

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have cytokine activity. Involved in BMP signaling pathway involved in heart development; cardiac atrium development; and cartilage morphogenesis. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in tooth agenesis. Is expressed in several structures, including digestive system; head; optic cup; optic vesicle; and swim bladder bud. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist).
Genome Resources: Alliance (1),  Gene:550399 (1),  Ensembl(GRCz11):ENSDARG00000103092 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-grem2b N/A 1
MO2-grem2b N/A 1
MO3-grem2b N/A 1
MO4-grem2b N/A 1
DISEASE ASSOCIATED WITH grem2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Tooth agenesis, selective, 9 617275
DISEASE ASSOCIATED WITH grem2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cardiac atrium development (more)
Cellular Component extracellular region (more)
Molecular Function cytokine activity (more)
GO Terms (all 8)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA grem2b-201 (1)    Ensembl 866
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM grem2b
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(UAS:grem2,cryaa:Cerulean) cryaa Ceruleangrem2b Danio rerio 1 2
MARKER RELATIONSHIPS
grem2b Contained in: [Fosmid] CH1073-333P16 (1) (order this), ZFOS-1233H1 (1)
grem2b Encodes: [EST] 088-d10-2 (1)
[cDNA] MGC:112207 (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001017704 (1) 883 bp
Genomic GenBank:CU565470 (1) 39937 bp
Select Tool
Polypeptide UniProtKB:A0A0B5JK45 (1) 166 aa
Sequence Clusters UniGene:83695 (1)
Sequence Information (all 18)
ORTHOLOGY for grem2b ( Chr: 12 )
CITATIONS (24)