ZFIN ID: ZDB-GENE-030910-2
Gene Name: dopamine receptor D2b
Gene Symbol: drd2b    Nomenclature History

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Previous Name: drd2c (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of cytosolic calcium ion concentration; and regulation of ion transport. Predicted to localize to glutamatergic synapse and integral component of presynaptic membrane. Is expressed in nervous system and notochord. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2).
Genome Resources: Alliance (1),  Gene:378719 (1),  Ensembl(GRCz11):ENSDARG00000011091 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13379 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13467 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-drd2b N/A 1
    PHENOTYPE
    Data: Fig. 3 from Liu et al., 2006
    Observed in:
    DISEASE ASSOCIATED WITH drd2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH drd2b VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA drd2b-201 (1)    Ensembl 1374
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM drd2b No data available
    MARKER RELATIONSHIPS
    drd2b Contained in: [BAC] DKEYP-84G8 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_197936 (1) 1374 nt
    Genomic GenBank:CT573185 (1) 184219 nt
    Select Tool
    Polypeptide UniProtKB:Q7T1A1 (1) 452 aa
    Sequence Information (all 12)
    ORTHOLOGY for drd2b ( Chr: 5 )
    CITATIONS (38)