ZFIN ID: ZDB-GENE-030904-9
Gene Name: ventral anterior homeobox 1
Gene Symbol: vax1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in camera-type eye morphogenesis; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nervous system development. Predicted to localize to nucleus. Is expressed in several structures, including eye; forebrain; forebrain neural keel; optic cup; and optic vesicle. Human ortholog(s) of this gene implicated in syndromic microphthalmia 11. Orthologous to human VAX1 (ventral anterior homeobox 1).
Genome Resources: Alliance (1),  Gene:373870 (1),  Ensembl(GRCz11):ENSDARG00000021916 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42915 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-vax1 N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH vax1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    syndromic microphthalmia 11 Alliance ?Microphthalmia, syndromic 11 614402
    DISEASE ASSOCIATED WITH vax1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vax1-201 (1)    Ensembl 2555
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vax1 No data available
    MARKER RELATIONSHIPS
    vax1 Contained in: [BAC] CH73-36G21 (1)
    vax1 Encodes: [cDNA] MGC:77277 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194410 (1) 2577 nt
    Genomic GenBank:CT574588 (1) 120853 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4I9B5 (1) 317 aa
    Sequence Information (all 13)
    ORTHOLOGY for vax1 ( Chr: 17 )
    CITATIONS (43)