Gene
cyp1b1
- ID
- ZDB-GENE-030902-1
- Name
- cytochrome P450, family 1, subfamily B, polypeptide 1
- Symbol
- cyp1b1 Nomenclature History
- Previous Names
-
- zgc:136223
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen and steroid hydroxylase activity. Acts upstream of or within eye development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; heart; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anterior segment dysgenesis 6 | Alliance | Anterior segment dysgenesis 6, multiple subtypes | 617315 |
| buphthalmos | Alliance | Glaucoma 3A, primary open angle, congenital, juvenile, or adult onset | 231300 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, E-class, group I, CYP1 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:B8JKD5 | InterPro | 526 | |||||
| UniProtKB:Q1JQ70 | InterPro | 526 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
cyp1b1-201
(1)
|
Ensembl | 3,257 nt | ||
| mRNA |
cyp1b1-202
(1)
|
Ensembl | 2,422 nt |
Interactions and Pathways
No data available
Plasmids
No data available