Gene
cyp1b1
- ID
- ZDB-GENE-030902-1
- Name
- cytochrome P450, family 1, subfamily B, polypeptide 1
- Symbol
- cyp1b1 Nomenclature History
- Previous Names
-
- zgc:136223
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable monooxygenase activity. Acts upstream of or within eye development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including digestive system; heart; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anterior segment dysgenesis 6 | Alliance | Anterior segment dysgenesis 6, multiple subtypes | 617315 |
| buphthalmos | Alliance | Glaucoma 3A, primary open angle, congenital, juvenile, or adult onset | 231300 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, E-class, group I, CYP1 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:B8JKD5
|
526 | |||||
|
UniProtKB:Q1JQ70
|
526 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| aberrant processed transcript |
cyp1b1-201
(1)
|
3257 nt | |
| mRNA |
cyp1b1-202
(1)
|
2422 nt |
Interactions and Pathways
No data available
Plasmids
No data available