Gene

cyp1b1

ID
ZDB-GENE-030902-1
Name
cytochrome P450, family 1, subfamily B, polypeptide 1
Symbol
cyp1b1 Nomenclature History
Previous Names
  • zgc:136223
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have monooxygenase activity. Involved in eye development. Predicted to localize to intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Is expressed in several structures, including digestive system; heart; immature eye; nervous system; and pleuroperitoneal region. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Williams et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyp1b1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
anterior segment dysgenesis 6 Alliance Anterior segment dysgenesis 6, multiple subtypes 617315
buphthalmos Alliance Glaucoma 3A, primary open angle, congenital, juvenile, or adult onset 231300
Associated With cyp1b1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Family IPR008066 Cytochrome P450, E-class, group I, CYP1
Family IPR032971 Cytochrome P450 1B1
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
Domain Details Per Protein
Protein Length Cytochrome P450 Cytochrome P450 1B1 Cytochrome P450, conserved site Cytochrome P450, E-class, group I Cytochrome P450, E-class, group I, CYP1 Cytochrome P450 superfamily
UniProtKB:Q1JQ70 526
UniProtKB:Q8QFQ1 110
UniProtKB:Q5GH26 526
UniProtKB:B8JKD5 526
UniProtKB:Q3ZMG7 526
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations