ZFIN ID: ZDB-GENE-030901-2
Gene Name: matrix metallopeptidase 14b (membrane-inserted)
Gene Symbol: mmp14b    Nomenclature History

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Previous Names: MT-MMPbeta, zMT-MMP-beta (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity and zinc ion binding activity. Involved in several processes, including anterior/posterior axis specification; cartilage development; and gastrulation. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in myocardial infarction. Is expressed in several structures, including axis; connective tissue cell; head; myoseptum; and tail bud. Orthologous to human MMP14 (matrix metallopeptidase 14).
Genome Resources: Alliance (1),  Gene:566945 (1),  Ensembl(GRCz11):ENSDARG00000008388 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2034 Point Mutation Unknown Premature Stop ENU
sa5721 Point Mutation Unknown Premature Stop ENU
sa39891 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2195 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mmp14b N/A 2
    MO2-mmp14b N/A 5
    MO3-mmp14b N/A 2
    MO4-mmp14b N/A 1
    DISEASE ASSOCIATED WITH mmp14b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Winchester syndrome 277950
    DISEASE ASSOCIATED WITH mmp14b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell migration (more)
    Cellular Component extracellular matrix (more)
    Molecular Function metallopeptidase activity (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
    Conserved_site IPR018486 Hemopexin, conserved site
    Domain IPR000585 Hemopexin-like domain
    Domain IPR001818 Peptidase M10, metallopeptidase
    Domain IPR002477 Peptidoglycan binding-like
    Domain IPR006026 Peptidase, metallopeptidase
    Domain IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
    Domain IPR033739 Peptidase M10A, catalytic domain
    Family IPR021190 Peptidase M10A
    Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
    Homologous_superfamily IPR036365 PGBD-like superfamily
    Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
    Repeat IPR018487 Hemopexin-like repeats
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mmp14b-201 (1)    Ensembl 4473
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mmp14b No data available
    MARKER RELATIONSHIPS
    mmp14b Contained in: [BAC] CH211-10E2 (1)
    mmp14b Encodes: [cDNA] MGC:193633 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194414 (1) 4342 nt
    Genomic GenBank:AL928674 (1) 205118 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B0R0I1 (1) 621 aa
    Sequence Information (all 15)
    ORTHOLOGY for mmp14b ( Chr: 2 )
    CITATIONS (42)