ZFIN ID: ZDB-GENE-030901-2
Gene Name: matrix metallopeptidase 14b (membrane-inserted)
Gene Symbol: mmp14b    Nomenclature History

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Previous Names: MT-MMPbeta, zMT-MMP-beta (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity and zinc ion binding activity. Involved in several processes, including anterior/posterior axis specification; cartilage development; and gastrulation. Predicted to localize to extracellular space. Is expressed in several structures, including axis; connective tissue cell; head; myoseptum; and tail bud. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).
Genome Resources: Alliance (1),  Gene:566945 (1),  Ensembl(GRCz11):ENSDARG00000008388 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2034 Point Mutation Unknown Premature Stop ENU
sa5721 Point Mutation Unknown Premature Stop ENU
sa39891 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2195 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mmp14b N/A 2
    MO2-mmp14b N/A 5
    MO3-mmp14b N/A 2
    MO4-mmp14b N/A 1
    DISEASE ASSOCIATED WITH mmp14b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Winchester syndrome 277950
    DISEASE ASSOCIATED WITH mmp14b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell migration involved in gastrulation (more)
    Cellular Component extracellular matrix (more)
    Molecular Function metallopeptidase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mmp14b-201 (1)    Ensembl 4473
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mmp14b No data available
    MARKER RELATIONSHIPS
    mmp14b Contained in: [BAC] CH211-10E2 (1)
    mmp14b Encodes: [cDNA] MGC:193633 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194414 (1) 4342 nt
    Genomic GenBank:AL928674 (1) 205118 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B0R0I1 (1) 621 aa
    Sequence Information (all 15)
    ORTHOLOGY for mmp14b ( Chr: 2 )
    CITATIONS (42)