Gene

map3k5

ID

ZDB-GENE-030827-3

Name

mitogen-activated protein kinase kinase kinase 5

Symbol

map3k5 Nomenclature History

Previous Names

Ask1 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have MAP kinase kinase kinase activity. Predicted to be involved in activation of MAPKK activity. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu797 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map3k5 Human Ortholog

No data available

Associated With map3k5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR025136	MAP3K, TRAFs-binding domain
Domain	IPR043969	MAP3K, PH domain
Domain	IPR046872	MAP3K, deoxyribohydrolase domain
Domain	IPR046873	MAP3K, HisK-N-like globin domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily

Domain Details Per Protein

Protein	Length	MAP3K, deoxyribohydrolase domain	MAP3K, HisK-N-like globin domain	MAP3K, PH domain	MAP3K, TRAFs-binding domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Sterile alpha motif/pointed domain superfamily
UniProtKB:E7F2L3 InterPro	1364
UniProtKB:A0A8M9P2K6 InterPro	1356

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	map3k5-201 (1) Ensembl	Ensembl	4,095 nt	Select Tool ZFIN BLAST
mRNA	map3k5-204 (1) Ensembl	Ensembl	5,774 nt	Select Tool
ncRNA	map3k5-002 (1) Ensembl	Ensembl	730 nt	Select Tool
ncRNA	map3k5-003 (1) Ensembl	Ensembl	930 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations