Gene

map3k5

ID
ZDB-GENE-030827-3
Name
mitogen-activated protein kinase kinase kinase 5
Symbol
map3k5 Nomenclature History
Previous Names
  • Ask1 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within defense response to bacterium. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With map3k5 Human Ortholog
No data available
Associated With map3k5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR025136 MAP3K, TRAFs-binding domain
Domain IPR043969 MAP3K, PH domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Domain Details Per Protein
Protein Length MAP3K, PH domain MAP3K, TRAFs-binding domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Sterile alpha motif/pointed domain superfamily
UniProtKB:R4GDS5 1356
UniProtKB:A0A2R8PY87 1351
UniProtKB:E7F2L3 1364
UniProtKB:A0A2R8Q2N6 1343
UniProtKB:A0A2R8PWM3 1340
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations