ZFIN ID: ZDB-GENE-030826-8
Gene Name: caspase 8 associated protein 2
Gene Symbol: casp8ap2    Nomenclature History

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Previous Names: fc74h10, FLASH, wu:fc74h10, zgc:113449

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have transcription corepressor activity. Predicted to be involved in Fas signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; and extrinsic apoptotic signaling pathway via death domain receptors. Predicted to localize to PML body and mitochondrion. Orthologous to human CASP8AP2 (caspase 8 associated protein 2).
Genome Resources: Alliance (1),  Gene:541521 (1),  Ensembl(GRCz11):ENSDARG00000022718 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:113449]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH casp8ap2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH casp8ap2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process apoptotic signaling pathway (more)
Cellular Component mitochondrion (more)
Molecular Function DNA binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA casp8ap2-201 (1)    Ensembl 6363
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM casp8ap2 No data available
MARKER RELATIONSHIPS
casp8ap2 Contained in: [BAC] DKEYP-117E10 (1)
casp8ap2 Encodes: [EST] fc74h10 (1)
[cDNA] MGC:113449 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001014334 (1) 6375 nt
Genomic GenBank:BX510339 (1) 70879 nt
Select Tool
Polypeptide UniProtKB:F1QD18 (1) 1995 aa
Sequence Information (all 17)
ORTHOLOGY for casp8ap2 ( Chr: 20 )
CITATIONS (26)