ZFIN ID: ZDB-GENE-030826-11
Gene Name: apoptosis inducing factor mitochondrion associated 1
Gene Symbol: aifm1    Nomenclature History

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Previous Names: AIF, pdcd8, zgc:91994

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have flavin adenine dinucleotide binding activity; oxidoreductase activity; and protein dimerization activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to integral component of membrane. Is expressed in several structures, including alar plate midbrain region; digestive system; hatching gland; musculature system; and polster. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1).
Genome Resources: Alliance (1),  Gene:373125 (1),  Ensembl(GRCz11):ENSDARG00000058088 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1710 Point Mutation Unknown Missense, Splice Site ENU
sa33579 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40408 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH aifm1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease X-linked recessive 4 Alliance Cowchock syndrome 310490
    combined oxidative phosphorylation deficiency 6 Alliance Combined oxidative phosphorylation deficiency 6 300816
    X-linked deafness 5 Alliance Deafness, X-linked 5 300614
    Spondyloepimetaphyseal dysplasia, X-linked, with hypomyelinating leukodystrophy 300232
    DISEASE ASSOCIATED WITH aifm1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function flavin adenine dinucleotide binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aifm1-203 (1)    Ensembl 2808
    aifm1-204 (1)    Ensembl 803
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aifm1 No data available
    MARKER RELATIONSHIPS
    aifm1 Contained in: [BAC] DKEY-103E21 (1) (order this)
    aifm1 Encodes: [EST] IMAGE:7157541 (1)
    [cDNA] MGC:91994 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200102 (1) 2815 nt
    Genomic GenBank:BX470076 (1) 112637 nt
    Select Tool
    Polypeptide UniProtKB:Q6TEP2 (1) 751 aa
    Sequence Information (all 27)
    ORTHOLOGY for aifm1 ( Chr: 5 )
    CITATIONS (35)