Gene

birc2

ID
ZDB-GENE-030825-6
Name
baculoviral IAP repeat containing 2
Symbol
birc2 Nomenclature History
Previous Names
  • birc3 (1)
  • IAP1 (1)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of necroptotic process; and positive regulation of protein ubiquitination. Predicted to localize to cytoplasm and nucleus. Is expressed in dorsal aorta; intersegmental vessel; and posterior cardinal vein. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to several human genes including BIRC2 (baculoviral IAP repeat containing 2).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With birc2 Human Ortholog
No data available
Associated With birc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001315 CARD domain
Domain IPR001841 Zinc finger, RING-type
Domain IPR041933 BIRC2/BIRC3, UBA domain
Homologous_superfamily IPR011029 Death-like domain superfamily
Repeat IPR001370 BIR repeat
Domain Details Per Protein
Protein Length BIRC2/BIRC3, UBA domain BIR repeat CARD domain Death-like domain superfamily Zinc finger, RING-type
UniProtKB:Q7T0K2 647
UniProtKB:Q8UWD2 628
UniProtKB:Q6ZM93 654
UniProtKB:A0A0R4I9H2 10
UniProtKB:A0A2R8QDZ3 633
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations