ZFIN ID: ZDB-GENE-030825-6
Gene Name: baculoviral IAP repeat containing 2
Gene Symbol: birc2    Nomenclature History

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Previous Names: birc3 (1), IAP1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of necroptotic process; and positive regulation of protein ubiquitination. Predicted to localize to cytoplasm and nucleus. Is expressed in dorsal aorta; intersegmental vessel; and posterior cardinal vein. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to several human genes including BIRC2 (baculoviral IAP repeat containing 2).
Genome Resources: Alliance (1),  Gene:373107 (1),  Ensembl(GRCz11):ENSDARG00000044619 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6903716]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2026aTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021887Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s805 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-birc2 N/A 2
    DISEASE ASSOCIATED WITH birc2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH birc2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of apoptotic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA birc2-201 (1)    Ensembl 2609
    birc2-202 (1)    Ensembl 2790
    birc2-203 (1)    Ensembl 832
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM birc2 No data available
    MARKER RELATIONSHIPS
    birc2 Contained in: [BAC] CH73-59N7 (1), DKEYP-69C1 (1), RP71-1P14
    birc2 Encodes: [EST] IMAGE:6903716 (1)
    [cDNA] MGC:136721 (1), MGC:152673 (1), MGC:193097 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194395 (1) 2620 nt
    Genomic GenBank:BX510940 (1) 172605 nt
    Select Tool
    Polypeptide UniProtKB:Q6ZM93 (1) 654 aa
    Sequence Information (all 35)
    ORTHOLOGY for birc2 ( Chr: 21 )
    CITATIONS (43)