| ZFIN ID: ZDB-GENE-030825-6 |
| Gene Name: | baculoviral IAP repeat containing 2 | |||||||||||||
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| Gene Symbol: | birc2 Nomenclature History |
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Attributions
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| Previous Names: | birc3 (1), IAP1 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 21 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of necroptotic process; and positive regulation of protein ubiquitination. Predicted to localize to cytoplasm and nucleus. Is expressed in dorsal aorta; intersegmental vessel; and posterior cardinal vein. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to several human genes including BIRC2 (baculoviral IAP repeat containing 2). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:373107 (1), Ensembl(GRCz11):ENSDARG00000044619 (1) | |||||||||||||
| All Expression Data: | 4 figures from 3 publications |
| Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6903716] |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) |
| High Throughput Expression: | GEO (1) , Expression Atlas (1) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| hi2026aTg | Transgenic Insertion | Intron 1 | Unknown | DNA |
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| la021887Tg | Transgenic Insertion | Unknown | Unknown | DNA |
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| s805 | Point Mutation | Unknown | Premature Stop | ENU |
PHENOTYPE
| Data: | 8 figures from 5 publications |
| Observed in: |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | regulation of apoptotic process (more) |
| Cellular Component | cytoplasm (more) |
| Molecular Function | metal ion binding (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
birc2-201
(1)
|
2609 |
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birc2-202
(1)
|
2790 |
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birc2-203
(1)
|
832 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM birc2
No data available
MARKER RELATIONSHIPS
| birc2 Contained in: | [BAC] CH73-59N7 (1), DKEYP-69C1 (1), RP71-1P14 |
| birc2 Encodes: |
[EST]
IMAGE:6903716 (1)
[cDNA] MGC:136721 (1), MGC:152673 (1), MGC:193097 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_194395 (1) | 2620 nt |
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| Genomic | GenBank:BX510940 (1) | 172605 nt | |
| Polypeptide | UniProtKB:Q6ZM93 (1) | 654 aa |
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ORTHOLOGY for birc2 (
Chr:
21
)
CITATIONS (43)