ZFIN ID: ZDB-GENE-030825-1
Gene Name: MCL1 apoptosis regulator, BCL2 family member b
Gene Symbol: mcl1b    Nomenclature History

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Previous Name: zgc:109763

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in chordate embryonic development; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and negative regulation of mitotic nuclear division. Predicted to localize to mitochondrial outer membrane. Is expressed in brain; digestive system; eye; heart; and pleuroperitoneal region. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member).
Genome Resources: Alliance (1),  Gene:373102 (1),  Ensembl(GRCz11):ENSDARG00000008363 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:109763]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-mcl1b N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mcl1b HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mcl1b VIA EXPERIMENTAL MODELS No data available
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mcl1b-201 (1)    Ensembl 742
mcl1b-202 (1)    Ensembl 1669
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mcl1b No data available
MARKER RELATIONSHIPS
mcl1b Contained in: [BAC] DKEY-30O16 (1) (order this)
mcl1b Encodes: [cDNA] MGC:109763 (1), MGC:192233 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_194394 (1) 1028 nt
Genomic GenBank:BX248517 (1) 201353 nt Blast at MegaBLAST
Polypeptide UniProtKB:A2BF68 (1) 228 aa
Sequence Information (all 17)
ORTHOLOGY for mcl1b ( Chr: 16 )
CITATIONS (35)