ZFIN ID: ZDB-GENE-030820-2
Gene Name: signal transducer and activator of transcription 5a
Gene Symbol: stat5a    Nomenclature History

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Previous Names: stat5.1, stat5b, sb:eu615

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including hemopoiesis; positive regulation of myeloid cell differentiation; and receptor signaling pathway via JAK-STAT. Predicted to localize to the cytosol and nucleus. Is expressed in adaxial cell and liver. Orthologous to human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B).
Genome Resources: Alliance (1),  Gene:369197 (1),  Ensembl(GRCz11):ENSDARG00000019392 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 7 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu615]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb393 Small Deletion Unknown Unknown CRISPR
ihb394 Small Deletion Unknown Frameshift, Premature Stop CRISPR
sa10709 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19972 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33126 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40029 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tpl4Gt Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-stat5a 1
    MO1-stat5a N/A 1
    MO2-stat5a N/A 2
    MO3-stat5a N/A 4
    DISEASE ASSOCIATED WITH stat5a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Growth hormone insensitivity with immunodeficiency 245590
    Leukemia, acute promyelocytic, somatic 102578
    DISEASE ASSOCIATED WITH stat5a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription by RNA polymerase II (more)
    Cellular Component cytoplasm (more)
    Molecular Function DNA binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000980 SH2 domain
    Domain IPR013799 STAT transcription factor, protein interaction
    Domain IPR013800 STAT transcription factor, all-alpha domain
    Domain IPR013801 STAT transcription factor, DNA-binding
    Family IPR001217 Transcription factor STAT
    Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
    Homologous_superfamily IPR012345 STAT transcription factor, DNA-binding, N-terminal
    Homologous_superfamily IPR015988 STAT transcription factor, coiled coil
    Homologous_superfamily IPR036535 STAT transcription factor, N-terminal domain superfamily
    Homologous_superfamily IPR036860 SH2 domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA stat5a-202 (1)    Ensembl 880
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM stat5a No data available
    MARKER RELATIONSHIPS
    stat5a Contained in: [BAC] CH73-271G12 (1), CH73-343F10 (1), DKEY-272F19 (1) (order this)
    stat5a Encodes: [EST] eu615 (1)
    [cDNA] MGC:193856 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194387 (1) 2844 nt
    Genomic RefSeq:NW_018394526 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:C0SPC8 (1) 785 aa
    Sequence Information (all 36)
    ORTHOLOGY for stat5a ( Chr: 3 )
    CITATIONS (48)