Gene

stat5a

ID
ZDB-GENE-030820-2
Name
signal transducer and activator of transcription 5a
Symbol
stat5a Nomenclature History
Previous Names
  • stat5.1
  • stat5b
  • sb:eu615
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within several processes, including hemopoiesis; positive regulation of myeloid cell differentiation; and receptor signaling pathway via JAK-STAT. Predicted to be located in cytoplasm and nucleus. Is expressed in adaxial cell and liver. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With stat5a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
growth hormone insensitivity syndrome with immune dysregulation 1 Alliance Growth hormone insensitivity with immune dysregulation 1, autosomal recessive 245590
growth hormone insensitivity syndrome with immune dysregulation 2 Alliance Growth hormone insensitivity with immune dysregulation 2, autosomal dominant 618985
Leukemia, acute promyelocytic, somatic 102578
Associated With stat5a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR013799 STAT transcription factor, protein interaction
Domain IPR013800 STAT transcription factor, all-alpha domain
Domain IPR013801 STAT transcription factor, DNA-binding
Family IPR001217 Transcription factor STAT
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012345 STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily IPR015988 STAT transcription factor, coiled coil
Homologous_superfamily IPR036535 STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding SH2 domain SH2 domain superfamily STAT transcription factor, all-alpha domain STAT transcription factor, coiled coil STAT transcription factor, DNA-binding STAT transcription factor, DNA-binding, N-terminal STAT transcription factor, N-terminal domain superfamily STAT transcription factor, protein interaction Transcription factor STAT
UniProtKB:Q68SP3 785
UniProtKB:Q7T3T3 785
UniProtKB:Q8UVW9 785
UniProtKB:C0SPC8 785
UniProtKB:F6NMQ4 226
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations