Gene
tp73
- ID
- ZDB-GENE-030814-2
- Name
- tumor protein p73
- Symbol
- tp73 Nomenclature History
- Previous Names
-
- TAp73 (1)
- sb:eu652
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Exhibits DNA-binding transcription factor activity. Involved in embryonic cranial skeleton morphogenesis and regulation of transcription, DNA-templated. Predicted to localize to transcription regulator complex. Is expressed in several structures, including gonad; musculature system; nervous system; pharynx; and renal system. Human ortholog(s) of this gene implicated in breast cancer; lung cancer; nephroblastoma; and renal cell carcinoma. Orthologous to human TP73 (tumor protein p73).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu652 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ciliary dyskinesia, primary, 47, and lissencephaly | 619466 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR010991 | p53, tetramerisation domain |
| Domain | IPR011615 | p53, DNA-binding domain |
| Family | IPR002117 | p53 tumour suppressor family |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012346 | p53/RUNT-type transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036674 | p53-like tetramerisation domain superfamily |
Domain Details Per Protein
| Protein | Length | p53, DNA-binding domain | p53-like tetramerisation domain superfamily | p53-like transcription factor, DNA-binding domain superfamily | p53/RUNT-type transcription factor, DNA-binding domain superfamily | p53, tetramerisation domain | p53 tumour suppressor family | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q801Z7
|
640 | ||||||||
|
UniProtKB:B0S576
|
640 | ||||||||
|
UniProtKB:A0A8M3AVI5
|
585 | ||||||||
|
UniProtKB:B0S577
|
555 |
Interactions and Pathways
No data available
Plasmids
No data available