Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030804-11
Gene Name: lamin B receptor
Gene Symbol: lbr
Previous Names: sb:cb406, wu:fb75h08, wu:fc47b04, wu:fd36b07, zgc:86649
Location: Chr: 20   Details
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (13 images) from Thisse et al., 2001 [cb406]
  6 figures (16 images) from Rauch et al., 2003 [fb83h10]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  brain, central nervous system, head mesenchyme, hindbrain (all 17) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa15675
Knockdown reagents: MO1-lbr (1)
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Greenberg skeletal dysplasia 215140
Pelger-Huet anomaly 169400
?Reynolds syndrome 613471
GENE ONTOLOGY
Ontology GO Term
Biological Process cell migration involved in gastrulation (more)
Cellular Component nuclear inner membrane (more)
Molecular Function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001171 (1)
  • InterPro:IPR018083 (1)
  • InterPro:IPR019023 (1)
  • PROSITE:PS01017 (1)
  • PROSITE:PS01018 (1)
  • Pfam:PF01222 (1)
  • Pfam:PF09465 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA lbr-001 (1) 3082
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM lbr No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    lbr Contained in: [BAC] DKEY-1J5 (1)
    lbr Contains: [SNP] rs3727636 (1), rs3727793 (1), rs3727794 (1)
    lbr Encodes: [EST] cb406 (1) (order this), fb75h08, fb83h10 (1), fc47b04, fd36b07
    [cDNA] MGC:86649 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002720 (1) 2475 bp
    Genomic GenBank:BX000468 (1) 208583 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5RJ97 (1) 619 aa
    Sequence Clusters UniGene:21958 (1)
    Sequence Information (all 22)
    OTHER lbr GENE PAGES
  • Gene:368360 (1)
  • VEGA:OTTDARG00000005684 (1)
  • Ensembl(Zv9):ENSDARG00000014013 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish lbr 20  
    Human LBR 1 (1q42.1)
  • OMIM:600024
  • Gene:3930
  • Mouse Lbr 1 ( 84.89 cM)
  • MGI:2138281
  • Gene:98386
  • Orthology Details
    CITATIONS (19)