ZFIN ID: ZDB-GENE-030804-11
Gene Name: lamin B receptor
Gene Symbol: lbr
Previous Names: sb:cb406, wu:fb75h08, wu:fc47b04, wu:fd36b07, zgc:86649
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (13 images) from Thisse et al., 2001 [cb406]
  6 figures (16 images) from Rauch et al., 2003 [fb83h10]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  brain, central nervous system, head mesenchyme, hindbrain (all 17) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
sa15675 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-lbr (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lbr HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Pelger-Huet anomaly Pelger-Huet anomaly 169400
    Greenberg skeletal dysplasia 215140
    ?Reynolds syndrome 613471
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process cell migration involved in gastrulation (more)
    Cellular Component nuclear inner membrane (more)
    Molecular Function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001171 (1)
  • InterPro:IPR018083 (1)
  • InterPro:IPR019023 (1)
  • PROSITE:PS01017 (1)
  • PROSITE:PS01018 (1)
  • Pfam:PF01222 (1)
  • Pfam:PF09465 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA lbr-001 (1) 3082
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lbr No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    lbrContained in: [BAC] DKEY-1J5 (1) (order this)
    lbrContains: [SNP] rs3727636 (1), rs3727793 (1), rs3727794 (1)
    lbrEncodes: [EST] cb406 (1) (order this), fb75h08, fb83h10 (1) (order this), fc47b04, fd36b07
    [cDNA] MGC:86649 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002720 (1) 2475bp
    Genomic GenBank:BX000468 (1) 208583bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5RJ97 (1) 619aa
    Sequence Clusters UniGene:21958 (1)
    Sequence Information (all 22)
    OTHER lbr GENE PAGES 
  • Gene:368360 (1)
  • VEGA:OTTDARG00000005684 (1)
  • Ensembl(GRCz10):ENSDARG00000014013 (1)
  • ORTHOLOGY for lbr (Chr: 20) 
    Species Symbol Chromosome Accession # Evidence
    Human LBR 1
  • Gene:3930
  • OMIM:600024
  • HGNC:6518
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (2)
    Mouse Lbr 1
  • MGI:2138281
  • Gene:98386
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (22)