ZFIN ID: ZDB-GENE-030804-11
Gene Name: lamin B receptor
Gene Symbol: lbr    Nomenclature History

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Previous Names: sb:cb406, wu:fb75h08, wu:fc47b04, wu:fd36b07, zgc:86649

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have oxidoreductase activity, acting on the CH-CH group of donors. Involved in cell migration involved in gastrulation. Localizes to nuclear inner membrane. Is expressed in several structures, including hypochord; nervous system; neural plate; optic vesicle; and tail bud. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cirrhosis. Orthologous to human LBR (lamin B receptor).
Genome Resources: Alliance (1),  Gene:368360 (1),  Ensembl(GRCz11):ENSDARG00000014013 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa15675 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa45712 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lbr N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lbr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Greenberg dysplasia Alliance Greenberg skeletal dysplasia 215140
    Pelger-Huet anomaly Alliance Pelger-Huet anomaly 169400
    Pelger-Huet anomaly with mild skeletal anomalies 618019
    ?Reynolds syndrome 613471
    DISEASE ASSOCIATED WITH lbr VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lbr-201 (1)    Ensembl 3082
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lbr No data available
    MARKER RELATIONSHIPS
    lbr Contained in: [BAC] DKEY-1J5 (1) (order this)
    lbr Contains: [SNP] rs3727636 (1), rs3727793 (1), rs3727794 (1)
    lbr Encodes: [EST] cb406 (1) (order this), fb75h08, fb83h10 (1) (order this), fc47b04, fd36b07
    [cDNA] MGC:86649 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002720 (1) 2475 nt
    Genomic GenBank:BX000468 (1) 208583 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5RJ97 (1) 619 aa
    Sequence Information (all 23)
    ORTHOLOGY for lbr ( Chr: 20 )
    CITATIONS (30)