Gene

gh1

ID
ZDB-GENE-030725-2
Name
growth hormone 1
Symbol
gh1 Nomenclature History
Previous Names
  • gh (1)
  • ghl
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Exhibits growth hormone activity and growth hormone receptor binding activity. Involved in adipose tissue development and positive regulation of lipid catabolic process. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune polyendocrine syndrome type 1; diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Is expressed in several structures, including adenohypophyseal placode; female organism; hematopoietic multipotent progenitor cell; hypophysis; and male organism. Orthologous to several human genes including GH1 (growth hormone 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
69 figures from 41 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gh1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated growth hormone deficiency type IA Alliance Growth hormone deficiency, isolated, type IA 262400
isolated growth hormone deficiency type IB Alliance Growth hormone deficiency, isolated, type IB 612781
isolated growth hormone deficiency type II Alliance Growth hormone deficiency, isolated, type II 173100
Kowarski syndrome 262650
Associated With gh1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018116 Somatotropin hormone, conserved site
Family IPR001400 Somatotropin/prolactin
Family IPR034975 Somatotropin
Homologous_superfamily IPR009079 Four-helical cytokine-like, core
Domain Details Per Protein
Protein Length Four-helical cytokine-like, core Somatotropin Somatotropin hormone, conserved site Somatotropin/prolactin
UniProtKB:Q571R1 210
UniProtKB:Q1JQ34 210
UniProtKB:Q7ZZH9 156
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations