ZFIN ID: ZDB-GENE-030725-2
Gene Name: growth hormone 1
Gene Symbol: gh1    Nomenclature History

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Previous Names: gh (1), ghl

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits growth hormone activity and growth hormone receptor binding activity. Involved in adipose tissue development and positive regulation of lipid catabolic process. Predicted to localize to extracellular space. Is expressed in several structures, including adenohypophyseal placode; female organism; hematopoietic multipotent progenitor cell; hypophysis; and male organism. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune polyendocrine syndrome type 1; diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1).
Genome Resources: Alliance (1),  Gene:407639 (1),  Ensembl(GRCz11):ENSDARG00000038185 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
umo8 Small Deletion Unknown Frameshift CRISPR
umo9 Small Deletion Unknown Unknown CRISPR
wp22e1 Point Mutation Exon 3 Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-gh1 1
CRISPR2-gh1 1
MO1-gh1 N/A 1
DISEASE ASSOCIATED WITH gh1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated growth hormone deficiency type IA Alliance Growth hormone deficiency, isolated, type IA 262400
isolated growth hormone deficiency type IB Alliance Growth hormone deficiency, isolated, type IB 612781
isolated growth hormone deficiency type II Alliance Growth hormone deficiency, isolated, type II 173100
Kowarski syndrome 262650
DISEASE ASSOCIATED WITH gh1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process adipose tissue development (more)
Cellular Component extracellular region (more)
Molecular Function growth hormone activity (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gh1-201 (1)    Ensembl 1197
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gh1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-2.2actb1:gh1,-2.2actb1:GFP) actb1 GFPgh1 Danio rerio 1 2
MARKER RELATIONSHIPS
gh1 Contained in: [BAC] DKEY-248K5 (order this)
gh1 Encodes: [cDNA] MGC:136327 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001020492 (1) 1210 nt
Genomic GenBank:BX005440 (1) 166695 nt
Select Tool
Polypeptide UniProtKB:Q1JQ34 (1) 210 aa
Sequence Information (all 13)
ORTHOLOGY for gh1 ( Chr: 3 )
CITATIONS (116)