ZFIN ID: ZDB-GENE-030723-4
Gene Name: transforming growth factor, beta 3
Gene Symbol: tgfb3    Nomenclature History

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Previous Names: tgf beta 3 (1), wu:fc78g09, zgc:92058

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have cytokine activity and type II transforming growth factor beta receptor binding activity. Involved in hematopoietic stem cell differentiation; regulation of cartilage development; and regulation of ossification. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Is expressed in several structures, including cardiovascular system; fin; head; immature eye; and nervous system. Orthologous to human TGFB3 (transforming growth factor beta 3).
Genome Resources: Alliance (1),  Gene:369195 (1),  Ensembl(GRCz11):ENSDARG00000019367 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3526 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1467 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36544 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tgfb3 N/A 1
    MO2-tgfb3 N/A 2
    MO3-tgfb3 N/A 1
    DISEASE ASSOCIATED WITH tgfb3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    arrhythmogenic right ventricular dysplasia 1 Alliance Arrhythmogenic right ventricular dysplasia 1 107970
    Loeys-Dietz syndrome 5 Alliance Loeys-Dietz syndrome 5 615582
    DISEASE ASSOCIATED WITH tgfb3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic stem cell differentiation (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017948 Transforming growth factor beta, conserved site
    Domain IPR001111 TGF-beta, propeptide
    Domain IPR001839 Transforming growth factor-beta, C-terminal
    Family IPR015615 Transforming growth factor-beta-related
    Family IPR015618 Transforming growth factor beta-3
    Family IPR016319 Transforming growth factor-beta
    Homologous_superfamily IPR029034 Cystine-knot cytokine
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tgfb3-201 (1)    Ensembl 2073
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tgfb3 No data available
    MARKER RELATIONSHIPS
    tgfb3 Contained in: [BAC] CH73-60D15 (1)
    [Fosmid] CH1073-297M1 (1)
    tgfb3 Encodes: [EST] fc78g09 (1), IMAGE:7150374 (1), tgf_beta_3 (1)
    [cDNA] MGC:92058 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194386 (1) 2035 nt
    Genomic GenBank:FP325132 (1) 35292 nt
    Select Tool
    Polypeptide UniProtKB:Q66I23 (1) 410 aa
    Sequence Information (all 18)
    ORTHOLOGY for tgfb3 ( Chr: 17 )
    CITATIONS (62)