Gene

tgfb3

ID
ZDB-GENE-030723-4
Name
transforming growth factor, beta 3
Symbol
tgfb3 Nomenclature History
Previous Names
  • tgf beta 3 (1)
  • wu:fc78g09
  • zgc:92058
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Involved in hematopoietic stem cell differentiation; regulation of cartilage development; and regulation of ossification. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; fin; head; immature eye; and nervous system. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Orthologous to human TGFB3 (transforming growth factor beta 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
37 figures from 20 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tgfb3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
arrhythmogenic right ventricular dysplasia 1 Alliance Arrhythmogenic right ventricular dysplasia 1 107970
Loeys-Dietz syndrome 5 Alliance Loeys-Dietz syndrome 5 615582
Associated With tgfb3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Family IPR015618 Transforming growth factor beta-3
Family IPR016319 Transforming growth factor-beta
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor-beta Transforming growth factor beta-3 Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:Q66I23 410
UniProtKB:Q7SZV3 410
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations