ZFIN ID: ZDB-GENE-030722-3
Gene Name: slit homolog 1a (Drosophila)
Gene Symbol: slit1a    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have Roundabout binding activity and heparin binding activity. Involved in cranial nerve morphogenesis and positive regulation of axon extension. Predicted to localize to the extracellular space. Is expressed in central nervous system and retinal ganglion cell layer. Orthologous to human SLIT1 (slit guidance ligand 1).
Genome Resources: Alliance (1),  Gene:556123 (1),  Ensembl(GRCz11):ENSDARG00000044954 (2)
DISEASE ASSOCIATED WITH slit1a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH slit1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cranial nerve morphogenesis (more)
Cellular Component extracellular region (more)
Molecular Function calcium ion binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000372 Leucine-rich repeat N-terminal domain
Domain IPR000483 Cysteine-rich flanking region, C-terminal
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR006207 Cystine knot, C-terminal
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA slit1a-202 (1)    Ensembl 6008
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM slit1a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
TgBAC(slit1a:Cre,myl7:Cerulean) myl7slit1a CeruleanCre Danio rerio 1 1
TgBAC(slit1a:GAL4-VP16,myl7:mCherry) myl7slit1a GAL4mCherryVP16 Danio rerio 1 1
MARKER RELATIONSHIPS
slit1a Contained in: [BAC] CH211-178H7 (1), DKEY-58O21 (1) (order this)
slit1a Encodes: [cDNA] MGC:195059 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001034968 (1) 6037 nt
Genomic GenBank:BX005147 (1) 147683 nt
Select Tool
Polypeptide UniProtKB:B3DJM7 (1) 1524 aa
Sequence Information (all 15)
ORTHOLOGY for slit1a ( Chr: 13 )
CITATIONS (47)