Gene

cxcl12b

ID
ZDB-GENE-030721-1
Name
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)
Symbol
cxcl12b Nomenclature History
Previous Names
  • SDF-1b (2)
  • SDF1b (1)
  • zgc:136720
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Exhibits chemoattractant activity. Involved in several processes, including Kupffer's vesicle development; blood vessel morphogenesis; and nervous system development. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; endoderm; head; and mesoderm. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
Genome Resources
Note
None
Expression
All Expression Data
44 figures from 26 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cxcl12b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{AIDS, resistance to} 609423
Associated With cxcl12b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001811 Chemokine interleukin-8-like domain
Domain IPR033899 CXC Chemokine domain
Family IPR039813 Stromal cell-derived factor 1
Homologous_superfamily IPR036048 Chemokine interleukin-8-like superfamily
Domain Details Per Protein
Protein Length Chemokine interleukin-8-like domain Chemokine interleukin-8-like superfamily CXC Chemokine domain Stromal cell-derived factor 1
UniProtKB:Q6V9B5 97
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations