ZFIN ID: ZDB-GENE-030721-1
Gene Name: chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)
Gene Symbol: cxcl12b    Nomenclature History

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Previous Names: SDF-1b (2), SDF1b (1), zgc:136720

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits chemoattractant activity. Involved in several processes, including Kupffer's vesicle development; blood vessel morphogenesis; and nervous system development. Predicted to localize to extracellular region. Is expressed in several structures, including cardiovascular system; central nervous system; endoderm; head; and mesoderm. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
Genome Resources: Alliance (1),  Gene:799354 (1),  Ensembl(GRCz11):ENSDARG00000055100 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mu100 Indel Exon 2 Frameshift, Premature Stop
sa1516 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14394 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24194 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37534 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cxcl12b N/A 17
    MO2-cxcl12b N/A 7
    MO3-cxcl12b N/A 1
    MO4-cxcl12b N/A 1
    MO5-cxcl12b N/A 3
    DISEASE ASSOCIATED WITH cxcl12b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {AIDS, resistance to} 609423
    DISEASE ASSOCIATED WITH cxcl12b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell migration involved in gastrulation (more)
    Cellular Component extracellular region (more)
    Molecular Function chemoattractant activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cxcl12b-201 (1)    Ensembl 2844
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cxcl12b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-3.5ubb:LOXP-Hsa.H2B-Cerulean-LOXP-cxcl12b) ubb Ceruleancxcl12bLOXP Danio rerioHomo sapiens 1 1
    Tg(hsp70l:cxcl12b-EGFP) hsp70l cxcl12bEGFP Danio rerio 3 7
    TgBAC(cxcl12b:Citrine) cxcl12b Citrine Danio rerio 1 3
    MARKER RELATIONSHIPS
    cxcl12b Contained in: [BAC] DKEY-44G23 (1) (order this)
    cxcl12b Encodes: [EST] eu806 (1), eu815 (1)
    [cDNA] MGC:136720 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_198068 (1) 3266 nt
    Genomic GenBank:AL953841 (1) 219929 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q6V9B5 (1) 97 aa
    Sequence Information (all 25)
    ORTHOLOGY for cxcl12b ( Chr: 22 )
    CITATIONS (104)