ZFIN ID: ZDB-GENE-030717-1
Gene Name: rho/rac guanine nucleotide exchange factor (GEF) 2
Gene Symbol: arhgef2    Nomenclature History

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Previous Names: fj11d04, si:ch211-198o19.3, wu:fj11d04 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity and microtubule binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of neuron differentiation; and regulation of Rho protein signal transduction. Predicted to localize to cytoskeleton and ruffle membrane. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2).
Genome Resources: Alliance (1),  Gene:561276 (1),  Ensembl(GRCz11):ENSDARG00000075819 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22746 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22747 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-arhgef2
    1
    CRISPR2-arhgef2
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH arhgef2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neurodevelopmental disorder with midbrain and hindbrain malformations Alliance ?Neurodevelopmental disorder with midbrain and hindbrain malformations 617523
    DISEASE ASSOCIATED WITH arhgef2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Cellular Component cytoskeleton (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arhgef2-201 (1)    Ensembl 3993
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arhgef2 No data available
    MARKER RELATIONSHIPS
    arhgef2 Contained in: [BAC] CH211-198O19 (1)
    arhgef2 Encodes: [EST] fj11d04
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_684678 (1) 3768 nt
    Genomic GenBank:AL845419 (1) 176379 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q3N3 (1) 902 aa
    Sequence Information (all 16)
    ORTHOLOGY for arhgef2 ( Chr: 16 )
    CITATIONS (19)