Gene

serpind1

ID
ZDB-GENE-030711-2
Name
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Symbol
serpind1 Nomenclature History
Previous Names
  • HCII (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within blood coagulation. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Cheng et al., 2006
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With serpind1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
heparin cofactor II deficiency Alliance Thrombophilia due to heparin cofactor II deficiency 612356
Associated With serpind1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023795 Serpin, conserved site
Domain IPR023796 Serpin domain
Domain IPR033831 Heparin cofactor II, serpin domain
Family IPR000215 Serpin family
Homologous_superfamily IPR036186 Serpin superfamily
Homologous_superfamily IPR042178 Serpin superfamily, domain 1
Homologous_superfamily IPR042185 Serpin superfamily, domain 2
Domain Details Per Protein
Protein Length Heparin cofactor II, serpin domain Serpin, conserved site Serpin domain Serpin family Serpin superfamily Serpin superfamily, domain 1 Serpin superfamily, domain 2
UniProtKB:Q8AYE2 507
UniProtKB:A9JTB6 507
UniProtKB:A7YQ79 507
UniProtKB:B0V3R7 507
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations