Gene
serpind1
- ID
- ZDB-GENE-030711-2
- Name
- serpin peptidase inhibitor, clade D (heparin cofactor), member 1
- Symbol
- serpind1 Nomenclature History
- Previous Names
-
- HCII (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to localize to extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 2 figures from Cheng et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
heparin cofactor II deficiency | Alliance | Thrombophilia 10 due to heparin cofactor II deficiency | 612356 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR023795 | Serpin, conserved site |
Domain | IPR023796 | Serpin domain |
Domain | IPR033831 | Heparin cofactor II, serpin domain |
Family | IPR000215 | Serpin family |
Homologous_superfamily | IPR036186 | Serpin superfamily |
Homologous_superfamily | IPR042178 | Serpin superfamily, domain 1 |
Homologous_superfamily | IPR042185 | Serpin superfamily, domain 2 |
Domain Details Per Protein
Protein | Length | Heparin cofactor II, serpin domain | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q8AYE2
|
507 | |||||||
UniProtKB:B0V3R7
|
507 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
serpind1-201
(1)
|
Havana | 2469 nt | |
mRNA |
serpind1-202
(1)
|
Ensembl | 2422 nt |
Interactions and Pathways
No data available
Plasmids
No data available