ZFIN ID: ZDB-GENE-030711-1
Gene Name: tissue factor pathway inhibitor a
Gene Symbol: tfpia    Nomenclature History

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Previous Names: tfpib, si:dz44f8.1, wu:fb92g01, zgc:152844, zgc:158592

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation and negative regulation of peptidase activity. Predicted to localize to extracellular space. Is expressed in caudal fin skeleton. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor).
Genome Resources: Alliance (1),  Gene:359833 (1),  Ensembl(GRCz11):ENSDARG00000034718 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Days 21-29 (21d-30d, 7.8mm, 10 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016594Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tfpia HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tfpia VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood coagulation (more)
    Cellular Component extracellular region (more)
    Molecular Function peptidase inhibitor activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ottdart00000001981 (1) 2081
    tfpia-201 (1)    Ensembl 2293
    ncRNA tfpia-002 (1)    Ensembl 467
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tfpia No data available
    MARKER RELATIONSHIPS
    tfpia Contained in: [BAC] CH211-7O19 (1), DKEY-249O24 (1) (order this)
    [PAC] BUSM1-44F8 (1)
    tfpia Encodes: [EST] fb92g01 (1)
    [cDNA] MGC:152844 (1), MGC:158592 (1), MGC:191634 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_182872 (1) 1801 nt
    Genomic GenBank:CT943665 (1) 150931 nt
    Select Tool
    Polypeptide UniProtKB:Q504K2 (1) 292 aa
    Sequence Information (all 34)
    ORTHOLOGY for tfpia ( Chr: 9 )
    CITATIONS (32)